Touria Ahaouari, Brenda Berendsen, Nicolaas Schaper, Hans Bosma, Marleen van Greevenbroek, Bastiaan de Galan, Miranda T. Schram, Hans Savelberg, Annemarie Koster
{"title":"2型糖尿病和周围神经病变与器械测量的身体活动和久坐行为的联合关联——马斯特里赫特研究","authors":"Touria Ahaouari, Brenda Berendsen, Nicolaas Schaper, Hans Bosma, Marleen van Greevenbroek, Bastiaan de Galan, Miranda T. Schram, Hans Savelberg, Annemarie Koster","doi":"10.1002/dmrr.70069","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Peripheral neuropathy (PN) is a common complication of type 2 diabetes mellitus (T2DM). In this study, we determined the independent and combined associations of T2DM and PN with device-based measures of physical activity levels and sedentary behaviour.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Cross-sectional data from The Maastricht Study were used (<i>N</i>: 6471, age 59.8 ± 8.8). T2DM was determined with an oral glucose tolerance test and PN was, using a neurothesiometer, defined as an impaired vibration perception threshold (iVPT), that is exceeding 25 V in either one or both halluces. Physical activity and sedentary behaviour outcomes were derived through 8 days of activPAL accelerometer measurement, worn 24 h/day. Multiple linear regression analyses were used with adjustment for demographic, lifestyle and health-related indicators.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In the fully adjusted model, the combined presence of T2DM and iVPT presented the lowest step count (−1407 steps/day [95% CI: −1851, −963]), and showed the lowest time in light-intensity (−27.2 min/day [−38.6, −15.8]) and moderate-to-vigorous physical activity (−9.5 min/day [−12.6, −6.5]). Moreover, those with both conditions had the highest sedentary time (+33.3 min/day [21.4, 45.2]) and longest sedentary bout durations (+1.0 min/bout [0.6, 1.4) compared with those without these conditions.</p>\n </section>\n \n <section>\n \n <h3> Discussion</h3>\n \n <p>T2DM and PN were both independently associated with lower levels of physical activity and higher levels of sedentary time. The combination of T2DM with PN was associated with particularly low levels of physical activity and higher levels of sedentary time, indicating an additive association. Strategies to improve physical activity in these individuals should address both conditions.</p>\n </section>\n </div>","PeriodicalId":11335,"journal":{"name":"Diabetes/Metabolism Research and Reviews","volume":"41 5","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dmrr.70069","citationCount":"0","resultStr":"{\"title\":\"Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour—The Maastricht Study\",\"authors\":\"Touria Ahaouari, Brenda Berendsen, Nicolaas Schaper, Hans Bosma, Marleen van Greevenbroek, Bastiaan de Galan, Miranda T. Schram, Hans Savelberg, Annemarie Koster\",\"doi\":\"10.1002/dmrr.70069\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Peripheral neuropathy (PN) is a common complication of type 2 diabetes mellitus (T2DM). In this study, we determined the independent and combined associations of T2DM and PN with device-based measures of physical activity levels and sedentary behaviour.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>Cross-sectional data from The Maastricht Study were used (<i>N</i>: 6471, age 59.8 ± 8.8). T2DM was determined with an oral glucose tolerance test and PN was, using a neurothesiometer, defined as an impaired vibration perception threshold (iVPT), that is exceeding 25 V in either one or both halluces. Physical activity and sedentary behaviour outcomes were derived through 8 days of activPAL accelerometer measurement, worn 24 h/day. Multiple linear regression analyses were used with adjustment for demographic, lifestyle and health-related indicators.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>In the fully adjusted model, the combined presence of T2DM and iVPT presented the lowest step count (−1407 steps/day [95% CI: −1851, −963]), and showed the lowest time in light-intensity (−27.2 min/day [−38.6, −15.8]) and moderate-to-vigorous physical activity (−9.5 min/day [−12.6, −6.5]). Moreover, those with both conditions had the highest sedentary time (+33.3 min/day [21.4, 45.2]) and longest sedentary bout durations (+1.0 min/bout [0.6, 1.4) compared with those without these conditions.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Discussion</h3>\\n \\n <p>T2DM and PN were both independently associated with lower levels of physical activity and higher levels of sedentary time. The combination of T2DM with PN was associated with particularly low levels of physical activity and higher levels of sedentary time, indicating an additive association. 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Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour—The Maastricht Study
Objective
Peripheral neuropathy (PN) is a common complication of type 2 diabetes mellitus (T2DM). In this study, we determined the independent and combined associations of T2DM and PN with device-based measures of physical activity levels and sedentary behaviour.
Materials and Methods
Cross-sectional data from The Maastricht Study were used (N: 6471, age 59.8 ± 8.8). T2DM was determined with an oral glucose tolerance test and PN was, using a neurothesiometer, defined as an impaired vibration perception threshold (iVPT), that is exceeding 25 V in either one or both halluces. Physical activity and sedentary behaviour outcomes were derived through 8 days of activPAL accelerometer measurement, worn 24 h/day. Multiple linear regression analyses were used with adjustment for demographic, lifestyle and health-related indicators.
Results
In the fully adjusted model, the combined presence of T2DM and iVPT presented the lowest step count (−1407 steps/day [95% CI: −1851, −963]), and showed the lowest time in light-intensity (−27.2 min/day [−38.6, −15.8]) and moderate-to-vigorous physical activity (−9.5 min/day [−12.6, −6.5]). Moreover, those with both conditions had the highest sedentary time (+33.3 min/day [21.4, 45.2]) and longest sedentary bout durations (+1.0 min/bout [0.6, 1.4) compared with those without these conditions.
Discussion
T2DM and PN were both independently associated with lower levels of physical activity and higher levels of sedentary time. The combination of T2DM with PN was associated with particularly low levels of physical activity and higher levels of sedentary time, indicating an additive association. Strategies to improve physical activity in these individuals should address both conditions.
期刊介绍:
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