富马酸二甲酯对光藻的毒理学效应：从胚胎到成虫的多阶段研究

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology Pub Date : 2025-07-17 DOI:10.1016/j.aquatox.2025.107511

Yilu Feng , Xianwei Li , Yuncheng Qian , Jialu Xu , Hezheng Zheng , Keda Chen , Jiyuan Wang , Ruiqi Weng , Qingzhi Zhao , Yijie Zhang , Xinyi Fei , Xiaofen Zhang , Hongyu Li

{"title":"富马酸二甲酯对光藻的毒理学效应：从胚胎到成虫的多阶段研究","authors":"Yilu Feng , Xianwei Li , Yuncheng Qian , Jialu Xu , Hezheng Zheng , Keda Chen , Jiyuan Wang , Ruiqi Weng , Qingzhi Zhao , Yijie Zhang , Xinyi Fei , Xiaofen Zhang , Hongyu Li","doi":"10.1016/j.aquatox.2025.107511","DOIUrl":null,"url":null,"abstract":"<div><div>Dimethyl Fumarate (DMF) is a widely used organic synthetic intermediate known for its low toxicity, high efficiency, and broad-spectrum antimicrobial properties. It is commonly applied in food preservation and medical treatments. However, with the increasing use of DMF, its toxic effects on living organisms have attracted more and more attention. Current studies on the toxicity of DMF in aquatic ecosystems mainly focus on fish, while research on gastropod mollusks is relatively limited. This study aims to evaluate the multiple toxicity effects of DMF on the <em>Biomphalaria glabrata</em>, including acute and chronic toxicity in adults, embryonic development, hemocyte changes, and histopathological effects. Chronic exposure significantly inhibits the growth and reproductive capacity of <em>B. glabrata</em>. During embryonic development, DMF significantly increases embryonic mortality (LC<sub>50</sub> = 6.026 mg/L, at 120 h) and causes delayed embryonic development. Histological observations reveal that DMF causes significant pathological damage to vital organs such as the hepatopancreas of <em>B. glabrata</em>. This study reveals the toxic effects of DMF on mollusks, providing significant data support for further mechanistic studies.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107511"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Toxicological effects of dimethyl fumarate in Biomphalaria glabrata: A multi-stage study from embryo to adult\",\"authors\":\"Yilu Feng , Xianwei Li , Yuncheng Qian , Jialu Xu , Hezheng Zheng , Keda Chen , Jiyuan Wang , Ruiqi Weng , Qingzhi Zhao , Yijie Zhang , Xinyi Fei , Xiaofen Zhang , Hongyu Li\",\"doi\":\"10.1016/j.aquatox.2025.107511\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Dimethyl Fumarate (DMF) is a widely used organic synthetic intermediate known for its low toxicity, high efficiency, and broad-spectrum antimicrobial properties. It is commonly applied in food preservation and medical treatments. However, with the increasing use of DMF, its toxic effects on living organisms have attracted more and more attention. Current studies on the toxicity of DMF in aquatic ecosystems mainly focus on fish, while research on gastropod mollusks is relatively limited. This study aims to evaluate the multiple toxicity effects of DMF on the <em>Biomphalaria glabrata</em>, including acute and chronic toxicity in adults, embryonic development, hemocyte changes, and histopathological effects. Chronic exposure significantly inhibits the growth and reproductive capacity of <em>B. glabrata</em>. During embryonic development, DMF significantly increases embryonic mortality (LC<sub>50</sub> = 6.026 mg/L, at 120 h) and causes delayed embryonic development. Histological observations reveal that DMF causes significant pathological damage to vital organs such as the hepatopancreas of <em>B. glabrata</em>. This study reveals the toxic effects of DMF on mollusks, providing significant data support for further mechanistic studies.</div></div>\",\"PeriodicalId\":248,\"journal\":{\"name\":\"Aquatic Toxicology\",\"volume\":\"287 \",\"pages\":\"Article 107511\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aquatic Toxicology\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0166445X25002759\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MARINE & FRESHWATER BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aquatic Toxicology","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0166445X25002759","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MARINE & FRESHWATER BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

富马酸二甲酯（DMF）是一种广泛使用的有机合成中间体，以其低毒、高效和广谱抗菌特性而闻名。它通常应用于食品保鲜和医疗。然而，随着DMF使用的增加，其对生物体的毒性作用越来越引起人们的关注。目前关于DMF对水生生态系统毒性的研究主要集中在鱼类，而对腹足类软体动物的研究相对较少。本研究旨在评价DMF对光斑生物phalaria的多重毒性作用，包括成人急性和慢性毒性、胚胎发育、血细胞变化和组织病理学影响。长期暴露显著地抑制了光斑蝽的生长和繁殖能力。在胚胎发育过程中，DMF显著提高胚胎死亡率（LC50 = 6.026 mg/L，在120h），导致胚胎发育延迟。组织学观察表明，DMF可引起重要器官的病理损伤，如肝胰腺。本研究揭示了DMF对软体动物的毒性作用，为进一步的机制研究提供了重要的数据支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Toxicological effects of dimethyl fumarate in Biomphalaria glabrata: A multi-stage study from embryo to adult

Dimethyl Fumarate (DMF) is a widely used organic synthetic intermediate known for its low toxicity, high efficiency, and broad-spectrum antimicrobial properties. It is commonly applied in food preservation and medical treatments. However, with the increasing use of DMF, its toxic effects on living organisms have attracted more and more attention. Current studies on the toxicity of DMF in aquatic ecosystems mainly focus on fish, while research on gastropod mollusks is relatively limited. This study aims to evaluate the multiple toxicity effects of DMF on the Biomphalaria glabrata, including acute and chronic toxicity in adults, embryonic development, hemocyte changes, and histopathological effects. Chronic exposure significantly inhibits the growth and reproductive capacity of B. glabrata. During embryonic development, DMF significantly increases embryonic mortality (LC₅₀ = 6.026 mg/L, at 120 h) and causes delayed embryonic development. Histological observations reveal that DMF causes significant pathological damage to vital organs such as the hepatopancreas of B. glabrata. This study reveals the toxic effects of DMF on mollusks, providing significant data support for further mechanistic studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.