{"title":"一堆用于三维类器官界面的硅网格","authors":"Yan Huang","doi":"10.1038/s41928-025-01429-8","DOIUrl":null,"url":null,"abstract":"<p>The researchers — who are based at imec and KU Leuven — fabricated a stack of four suspended silicon meshes with 256 island electrodes via 130 nm complementary metal–oxide–semiconductor (CMOS) technology and deep reactive-ion etching. Multiplexing and circuit reuse techniques were used to implement different working modes. The MEA showed a low input-referred noise of 9.1 ± 1.5 μV<sub>rms</sub> (0.3–10 kHz) and power consumption of 11.3 μW per island. An in vitro demonstration in cultured cardiomyocytes showed that the system could record intracellular activity under voltage stimulation and track network propagation.</p><p><b>Original reference:</b> An active silicon perforated MEA for seamless 3D organoid interfacing with low-noise, scalable multimodal electrophysiology. In <i>Proc. 2025 IEEE Symposium on VLSI Technology & Circuits</i> (2025); https://www.vlsisymposium.org/</p>","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"52 1","pages":""},"PeriodicalIF":40.9000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A stack of silicon meshes for 3D organoid interfacing\",\"authors\":\"Yan Huang\",\"doi\":\"10.1038/s41928-025-01429-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The researchers — who are based at imec and KU Leuven — fabricated a stack of four suspended silicon meshes with 256 island electrodes via 130 nm complementary metal–oxide–semiconductor (CMOS) technology and deep reactive-ion etching. Multiplexing and circuit reuse techniques were used to implement different working modes. The MEA showed a low input-referred noise of 9.1 ± 1.5 μV<sub>rms</sub> (0.3–10 kHz) and power consumption of 11.3 μW per island. An in vitro demonstration in cultured cardiomyocytes showed that the system could record intracellular activity under voltage stimulation and track network propagation.</p><p><b>Original reference:</b> An active silicon perforated MEA for seamless 3D organoid interfacing with low-noise, scalable multimodal electrophysiology. In <i>Proc. 2025 IEEE Symposium on VLSI Technology & Circuits</i> (2025); https://www.vlsisymposium.org/</p>\",\"PeriodicalId\":19064,\"journal\":{\"name\":\"Nature Electronics\",\"volume\":\"52 1\",\"pages\":\"\"},\"PeriodicalIF\":40.9000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Electronics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1038/s41928-025-01429-8\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Electronics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1038/s41928-025-01429-8","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
A stack of silicon meshes for 3D organoid interfacing
The researchers — who are based at imec and KU Leuven — fabricated a stack of four suspended silicon meshes with 256 island electrodes via 130 nm complementary metal–oxide–semiconductor (CMOS) technology and deep reactive-ion etching. Multiplexing and circuit reuse techniques were used to implement different working modes. The MEA showed a low input-referred noise of 9.1 ± 1.5 μVrms (0.3–10 kHz) and power consumption of 11.3 μW per island. An in vitro demonstration in cultured cardiomyocytes showed that the system could record intracellular activity under voltage stimulation and track network propagation.
Original reference: An active silicon perforated MEA for seamless 3D organoid interfacing with low-noise, scalable multimodal electrophysiology. In Proc. 2025 IEEE Symposium on VLSI Technology & Circuits (2025); https://www.vlsisymposium.org/
期刊介绍：
Nature Electronics is a comprehensive journal that publishes both fundamental and applied research in the field of electronics. It encompasses a wide range of topics, including the study of new phenomena and devices, the design and construction of electronic circuits, and the practical applications of electronics. In addition, the journal explores the commercial and industrial aspects of electronics research.
The primary focus of Nature Electronics is on the development of technology and its potential impact on society. The journal incorporates the contributions of scientists, engineers, and industry professionals, offering a platform for their research findings. Moreover, Nature Electronics provides insightful commentary, thorough reviews, and analysis of the key issues that shape the field, as well as the technologies that are reshaping society.
Like all journals within the prestigious Nature brand, Nature Electronics upholds the highest standards of quality. It maintains a dedicated team of professional editors and follows a fair and rigorous peer-review process. The journal also ensures impeccable copy-editing and production, enabling swift publication. Additionally, Nature Electronics prides itself on its editorial independence, ensuring unbiased and impartial reporting.
In summary, Nature Electronics is a leading journal that publishes cutting-edge research in electronics. With its multidisciplinary approach and commitment to excellence, the journal serves as a valuable resource for scientists, engineers, and industry professionals seeking to stay at the forefront of advancements in the field.
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