Hou-Yu Zhou, You-Quan Zhao, Xiao-Chuan Wang, Shao Zhang, Jun Li
{"title":"中国学龄前儿童尿路结石复发的高危因素:中期随访调查结果","authors":"Hou-Yu Zhou, You-Quan Zhao, Xiao-Chuan Wang, Shao Zhang, Jun Li","doi":"10.21037/tau-2024-650","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To date, most literature has focused on factors contributing to the initial occurrence of pediatric urinary stones. However, there is scant literature on the risk factors for recurrence following the initial episode. Effective treatment strategies for the initial episode and measures to reduce the risk of stone recurrence are crucial. This study aimed to investigate the impact of children's dietary habits on the recurrence of urinary stones in children.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of pediatric patients diagnosed with urinary stones by the Department of Urology at Beijing Friendship Hospital Affiliated with Capital Medical University from January 2014 to December 2023. Dietary habits were compared between patients who experienced recurrence and those who did not.</p><p><strong>Results: </strong>We conducted a follow-up study from January 2014 to December 2023 on 310 children with urinary stones. During the follow-up period, which had a median duration of 50.93±1.79 months, 62 patients (20.0%) experienced recurrence, while 248 patients (80.0%) did not. Among the recurrent patients, 9 (14.5%) did not consume animal proteins, 21 (33.9%) had low water intake, and 34 (54.8%) had a high dietary oxalate intake. In comparison, among the non-recurrent patients, 34 (13.7%) did not consume animal proteins, 36 (14.5%) had low water intake, and 120 (48.4%) had a high dietary oxalate intake. Univariate analysis revealed that a high-protein diet [odds ratio (OR) =0.805, 95% confidence interval (CI): 0.707-0.917, P<0.001] was a protective factor against recurrence, while a high oxalate diet (OR =1.335, 95% CI: 1.146-1.554, P<0.001), low water intake (OR =1.138, 95% CI: 1.013-1.279, P=0.03), and younger age at onset (OR =1.062, 95% CI: 1.025-1.110, P=0.001) were identified as risk factors. In multivariate analysis, the high-protein diet remained a protective factor (OR =0.825, 95% CI: 0.725-0.940, P=0.004), while high dietary oxalate intake (OR =1.304, 95% CI: 1.122-1.515, P<0.001), low water intake (OR =1.141, 95% CI: 1.019-1.276, P=0.02), and younger age at onset (OR =1.076, 95% CI: 1.038-1.114, P<0.001) continued to be significant risk factors.</p><p><strong>Conclusions: </strong>The study concluded that a high-protein diet serves as a protective factor, whereas a high oxalate diet, low water intake, and younger age at onset are significant risk factors for the recurrence of pediatric urinary stones. The cumulative five-year recurrence rate of pediatric urinary stones was 18.1%. Therefore, dietary modifications, including increased protein intake and reduced oxalate consumption, along with ensuring adequate hydration, are crucial in managing pediatric urinary stones and preventing early recurrence.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 6","pages":"1601-1609"},"PeriodicalIF":1.7000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271954/pdf/","citationCount":"0","resultStr":"{\"title\":\"High-risk factors for urinary calculus recurrence in Chinese preschool children: findings from a medium-term follow-up survey.\",\"authors\":\"Hou-Yu Zhou, You-Quan Zhao, Xiao-Chuan Wang, Shao Zhang, Jun Li\",\"doi\":\"10.21037/tau-2024-650\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>To date, most literature has focused on factors contributing to the initial occurrence of pediatric urinary stones. However, there is scant literature on the risk factors for recurrence following the initial episode. Effective treatment strategies for the initial episode and measures to reduce the risk of stone recurrence are crucial. This study aimed to investigate the impact of children's dietary habits on the recurrence of urinary stones in children.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of pediatric patients diagnosed with urinary stones by the Department of Urology at Beijing Friendship Hospital Affiliated with Capital Medical University from January 2014 to December 2023. Dietary habits were compared between patients who experienced recurrence and those who did not.</p><p><strong>Results: </strong>We conducted a follow-up study from January 2014 to December 2023 on 310 children with urinary stones. During the follow-up period, which had a median duration of 50.93±1.79 months, 62 patients (20.0%) experienced recurrence, while 248 patients (80.0%) did not. Among the recurrent patients, 9 (14.5%) did not consume animal proteins, 21 (33.9%) had low water intake, and 34 (54.8%) had a high dietary oxalate intake. In comparison, among the non-recurrent patients, 34 (13.7%) did not consume animal proteins, 36 (14.5%) had low water intake, and 120 (48.4%) had a high dietary oxalate intake. Univariate analysis revealed that a high-protein diet [odds ratio (OR) =0.805, 95% confidence interval (CI): 0.707-0.917, P<0.001] was a protective factor against recurrence, while a high oxalate diet (OR =1.335, 95% CI: 1.146-1.554, P<0.001), low water intake (OR =1.138, 95% CI: 1.013-1.279, P=0.03), and younger age at onset (OR =1.062, 95% CI: 1.025-1.110, P=0.001) were identified as risk factors. In multivariate analysis, the high-protein diet remained a protective factor (OR =0.825, 95% CI: 0.725-0.940, P=0.004), while high dietary oxalate intake (OR =1.304, 95% CI: 1.122-1.515, P<0.001), low water intake (OR =1.141, 95% CI: 1.019-1.276, P=0.02), and younger age at onset (OR =1.076, 95% CI: 1.038-1.114, P<0.001) continued to be significant risk factors.</p><p><strong>Conclusions: </strong>The study concluded that a high-protein diet serves as a protective factor, whereas a high oxalate diet, low water intake, and younger age at onset are significant risk factors for the recurrence of pediatric urinary stones. The cumulative five-year recurrence rate of pediatric urinary stones was 18.1%. Therefore, dietary modifications, including increased protein intake and reduced oxalate consumption, along with ensuring adequate hydration, are crucial in managing pediatric urinary stones and preventing early recurrence.</p>\",\"PeriodicalId\":23270,\"journal\":{\"name\":\"Translational andrology and urology\",\"volume\":\"14 6\",\"pages\":\"1601-1609\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271954/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational andrology and urology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/tau-2024-650\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ANDROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational andrology and urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tau-2024-650","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/26 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ANDROLOGY","Score":null,"Total":0}
High-risk factors for urinary calculus recurrence in Chinese preschool children: findings from a medium-term follow-up survey.
Background: To date, most literature has focused on factors contributing to the initial occurrence of pediatric urinary stones. However, there is scant literature on the risk factors for recurrence following the initial episode. Effective treatment strategies for the initial episode and measures to reduce the risk of stone recurrence are crucial. This study aimed to investigate the impact of children's dietary habits on the recurrence of urinary stones in children.
Methods: A retrospective analysis was conducted on the clinical data of pediatric patients diagnosed with urinary stones by the Department of Urology at Beijing Friendship Hospital Affiliated with Capital Medical University from January 2014 to December 2023. Dietary habits were compared between patients who experienced recurrence and those who did not.
Results: We conducted a follow-up study from January 2014 to December 2023 on 310 children with urinary stones. During the follow-up period, which had a median duration of 50.93±1.79 months, 62 patients (20.0%) experienced recurrence, while 248 patients (80.0%) did not. Among the recurrent patients, 9 (14.5%) did not consume animal proteins, 21 (33.9%) had low water intake, and 34 (54.8%) had a high dietary oxalate intake. In comparison, among the non-recurrent patients, 34 (13.7%) did not consume animal proteins, 36 (14.5%) had low water intake, and 120 (48.4%) had a high dietary oxalate intake. Univariate analysis revealed that a high-protein diet [odds ratio (OR) =0.805, 95% confidence interval (CI): 0.707-0.917, P<0.001] was a protective factor against recurrence, while a high oxalate diet (OR =1.335, 95% CI: 1.146-1.554, P<0.001), low water intake (OR =1.138, 95% CI: 1.013-1.279, P=0.03), and younger age at onset (OR =1.062, 95% CI: 1.025-1.110, P=0.001) were identified as risk factors. In multivariate analysis, the high-protein diet remained a protective factor (OR =0.825, 95% CI: 0.725-0.940, P=0.004), while high dietary oxalate intake (OR =1.304, 95% CI: 1.122-1.515, P<0.001), low water intake (OR =1.141, 95% CI: 1.019-1.276, P=0.02), and younger age at onset (OR =1.076, 95% CI: 1.038-1.114, P<0.001) continued to be significant risk factors.
Conclusions: The study concluded that a high-protein diet serves as a protective factor, whereas a high oxalate diet, low water intake, and younger age at onset are significant risk factors for the recurrence of pediatric urinary stones. The cumulative five-year recurrence rate of pediatric urinary stones was 18.1%. Therefore, dietary modifications, including increased protein intake and reduced oxalate consumption, along with ensuring adequate hydration, are crucial in managing pediatric urinary stones and preventing early recurrence.
期刊介绍:
ranslational Andrology and Urology (Print ISSN 2223-4683; Online ISSN 2223-4691; Transl Androl Urol; TAU) is an open access, peer-reviewed, bi-monthly journal (quarterly published from Mar.2012 - Dec. 2014). The main focus of the journal is to describe new findings in the field of translational research of Andrology and Urology, provides current and practical information on basic research and clinical investigations of Andrology and Urology. Specific areas of interest include, but not limited to, molecular study, pathology, biology and technical advances related to andrology and urology. Topics cover range from evaluation, prevention, diagnosis, therapy, prognosis, rehabilitation and future challenges to urology and andrology. Contributions pertinent to urology and andrology are also included from related fields such as public health, basic sciences, education, sociology, and nursing.