{"title":"从中药中分离的螺酮类天然产物：分离、生物活性、生物合成和合成。","authors":"Eilidh G Young, Freda F Li, Margaret A Brimble","doi":"10.1039/d5np00035a","DOIUrl":null,"url":null,"abstract":"<p><p>Covering: 2010 to December 2024Traditional Chinese medicine is an ancient knowledge base of therapeutic plants and preparations. Today, the isolation of bioactive natural products from traditional Chinese medicine is a valuable tool to identify new scaffolds for drug discovery. One such scaffold, the spiroketal moiety, is widespread in bioactive natural products, often crucial to the bioactivity of the compound. The convergent evolution of the spiroketal moiety in natural products arising from diverse phylogenetic and biosynthetic origins is a hallmark of the biological importance of this moiety. This review aims to highlight the diverse biosynthetic origins and ensuant structural diversity of spiroketal natural products isolated from traditional Chinese medicine, along with their potent and wide array of biological activities, and synthetic approaches to access these natural products to date.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spiroketal natural products isolated from traditional Chinese medicine: isolation, biological activity, biosynthesis, and synthesis.\",\"authors\":\"Eilidh G Young, Freda F Li, Margaret A Brimble\",\"doi\":\"10.1039/d5np00035a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Covering: 2010 to December 2024Traditional Chinese medicine is an ancient knowledge base of therapeutic plants and preparations. Today, the isolation of bioactive natural products from traditional Chinese medicine is a valuable tool to identify new scaffolds for drug discovery. One such scaffold, the spiroketal moiety, is widespread in bioactive natural products, often crucial to the bioactivity of the compound. The convergent evolution of the spiroketal moiety in natural products arising from diverse phylogenetic and biosynthetic origins is a hallmark of the biological importance of this moiety. This review aims to highlight the diverse biosynthetic origins and ensuant structural diversity of spiroketal natural products isolated from traditional Chinese medicine, along with their potent and wide array of biological activities, and synthetic approaches to access these natural products to date.</p>\",\"PeriodicalId\":94,\"journal\":{\"name\":\"Natural Product Reports\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":10.6000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Reports\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5np00035a\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5np00035a","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Spiroketal natural products isolated from traditional Chinese medicine: isolation, biological activity, biosynthesis, and synthesis.
Covering: 2010 to December 2024Traditional Chinese medicine is an ancient knowledge base of therapeutic plants and preparations. Today, the isolation of bioactive natural products from traditional Chinese medicine is a valuable tool to identify new scaffolds for drug discovery. One such scaffold, the spiroketal moiety, is widespread in bioactive natural products, often crucial to the bioactivity of the compound. The convergent evolution of the spiroketal moiety in natural products arising from diverse phylogenetic and biosynthetic origins is a hallmark of the biological importance of this moiety. This review aims to highlight the diverse biosynthetic origins and ensuant structural diversity of spiroketal natural products isolated from traditional Chinese medicine, along with their potent and wide array of biological activities, and synthetic approaches to access these natural products to date.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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