{"title":"水热合成绿原酸功能化银纳米颗粒及其抗菌活性研究","authors":"Shengkai Liu, Hongji Wang, Siqi He, Xiaoyu Li, Liying Cui, Zhongkai Liu, Xiaoshuai Wang, Mengqi Liu, Yujie Fu, Zhiguo Liu","doi":"10.1002/jbm.b.35616","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>In this study, chlorogenic acid (CGA), a natural organic acid, was employed as both a reducing and stabilizing agent to synthesize chlorogenic acid-functionalized silver nanoparticles (CGA-AgNPs). The synthesis conditions of CGA-AgNPs, including reactant ratio, pH, temperature, and reaction time, were optimized. The synthesized CGA-functionalized AgNPs were characterized by ultraviolet–visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). TEM imaging results indicated that CGA-AgNPs were spherical nanoparticles with an average diameter of 36.70 ± 0.65 nm. FTIR spectroscopy results confirmed that CGA was covered on the surface of AgNPs. XPS results indicated that the surface of nanoparticles was made up of Ag atoms. The inhibitory activity of CGA-AgNPs against <i>Candida albicans</i> (<i>C. albicans</i>), <i>Acinetobacter baumanniiand</i> (<i>A. baumannii</i>), and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) was measured and evaluated by the inhibition circle method and the minimum inhibitory concentration. The synthesized CGA-AgNPs under optimal conditions indicated good antibacterial activity against <i>C. albicans, A. baumannii</i>, and <i>S. aureus</i> with MIC values of 36.95 ± 0.22 μg/mL and MBC values of 73.90 ± 0.22 μg/mL. In summary, this study provides a facile and green synthesis method to prepare CGA-AgNPs with excellent antibacterial activities.</p>\n </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydrothermal Synthesis of Chlorogenic Acid-Functionalized Ag Nanoparticles and Their Antibacterial Activity\",\"authors\":\"Shengkai Liu, Hongji Wang, Siqi He, Xiaoyu Li, Liying Cui, Zhongkai Liu, Xiaoshuai Wang, Mengqi Liu, Yujie Fu, Zhiguo Liu\",\"doi\":\"10.1002/jbm.b.35616\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>In this study, chlorogenic acid (CGA), a natural organic acid, was employed as both a reducing and stabilizing agent to synthesize chlorogenic acid-functionalized silver nanoparticles (CGA-AgNPs). The synthesis conditions of CGA-AgNPs, including reactant ratio, pH, temperature, and reaction time, were optimized. The synthesized CGA-functionalized AgNPs were characterized by ultraviolet–visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). TEM imaging results indicated that CGA-AgNPs were spherical nanoparticles with an average diameter of 36.70 ± 0.65 nm. FTIR spectroscopy results confirmed that CGA was covered on the surface of AgNPs. XPS results indicated that the surface of nanoparticles was made up of Ag atoms. The inhibitory activity of CGA-AgNPs against <i>Candida albicans</i> (<i>C. albicans</i>), <i>Acinetobacter baumanniiand</i> (<i>A. baumannii</i>), and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) was measured and evaluated by the inhibition circle method and the minimum inhibitory concentration. The synthesized CGA-AgNPs under optimal conditions indicated good antibacterial activity against <i>C. albicans, A. baumannii</i>, and <i>S. aureus</i> with MIC values of 36.95 ± 0.22 μg/mL and MBC values of 73.90 ± 0.22 μg/mL. In summary, this study provides a facile and green synthesis method to prepare CGA-AgNPs with excellent antibacterial activities.</p>\\n </div>\",\"PeriodicalId\":15269,\"journal\":{\"name\":\"Journal of biomedical materials research. Part B, Applied biomaterials\",\"volume\":\"113 8\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical materials research. Part B, Applied biomaterials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35616\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical materials research. Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35616","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Hydrothermal Synthesis of Chlorogenic Acid-Functionalized Ag Nanoparticles and Their Antibacterial Activity
In this study, chlorogenic acid (CGA), a natural organic acid, was employed as both a reducing and stabilizing agent to synthesize chlorogenic acid-functionalized silver nanoparticles (CGA-AgNPs). The synthesis conditions of CGA-AgNPs, including reactant ratio, pH, temperature, and reaction time, were optimized. The synthesized CGA-functionalized AgNPs were characterized by ultraviolet–visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). TEM imaging results indicated that CGA-AgNPs were spherical nanoparticles with an average diameter of 36.70 ± 0.65 nm. FTIR spectroscopy results confirmed that CGA was covered on the surface of AgNPs. XPS results indicated that the surface of nanoparticles was made up of Ag atoms. The inhibitory activity of CGA-AgNPs against Candida albicans (C. albicans), Acinetobacter baumanniiand (A. baumannii), and Staphylococcus aureus (S. aureus) was measured and evaluated by the inhibition circle method and the minimum inhibitory concentration. The synthesized CGA-AgNPs under optimal conditions indicated good antibacterial activity against C. albicans, A. baumannii, and S. aureus with MIC values of 36.95 ± 0.22 μg/mL and MBC values of 73.90 ± 0.22 μg/mL. In summary, this study provides a facile and green synthesis method to prepare CGA-AgNPs with excellent antibacterial activities.
期刊介绍：
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats:
• original research reports
• short research and development reports
• scientific reviews
• current concepts articles
• special reports
• editorials
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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