一种改进的、简洁的、可扩展的丹酚酸F全合成方法

IF 1.9 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-07-21 DOI:10.1002/slct.202503300

Huanjun Xu, Caicui Li, Yao Cheng, Xiaodan Wang, Xue Wang, Wei Sun, Lijuan Wang, Yiying Li, Wubo Wan, Jinhui Wang

{"title":"一种改进的、简洁的、可扩展的丹酚酸F全合成方法","authors":"Huanjun Xu, Caicui Li, Yao Cheng, Xiaodan Wang, Xue Wang, Wei Sun, Lijuan Wang, Yiying Li, Wubo Wan, Jinhui Wang","doi":"10.1002/slct.202503300","DOIUrl":null,"url":null,"abstract":"Salvianolic acid F (Sal-F) is one of the most active components in the traditional Chinese medicine Danshen, and is a key intermediate in the synthesis of salvianolic acid A (Sal-A). In this paper, a simple, efficient, and scalable route for the total synthesis of Sal-F was developed. The total synthesis of Sal-F was done through only 5 steps with high overall yield (45%). This synthetic technology was started from inexpensive materials, in which, some unpleasant reactants such as Br2 and n-BuLi were avoided. More importantly, this protocol was also applicable for 19 gram-scale synthesis. This protocol is crucial for the synthesis of Sal-A.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An Improved, Concise, and Scalable Approach for the Total Synthesis of Salvianolic Acid F\",\"authors\":\"Huanjun Xu, Caicui Li, Yao Cheng, Xiaodan Wang, Xue Wang, Wei Sun, Lijuan Wang, Yiying Li, Wubo Wan, Jinhui Wang\",\"doi\":\"10.1002/slct.202503300\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Salvianolic acid F (Sal-F) is one of the most active components in the traditional Chinese medicine Danshen, and is a key intermediate in the synthesis of salvianolic acid A (Sal-A). In this paper, a simple, efficient, and scalable route for the total synthesis of Sal-F was developed. The total synthesis of Sal-F was done through only 5 steps with high overall yield (45%). This synthetic technology was started from inexpensive materials, in which, some unpleasant reactants such as Br2 and n-BuLi were avoided. More importantly, this protocol was also applicable for 19 gram-scale synthesis. This protocol is crucial for the synthesis of Sal-A.\",\"PeriodicalId\":146,\"journal\":{\"name\":\"ChemistrySelect\",\"volume\":\"10 28\",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemistrySelect\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/slct.202503300\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistrySelect","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/slct.202503300","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

丹酚酸F （Salvianolic acid F, Sal-F）是中药丹参中最具活性的成分之一，是合成丹酚酸a （Salvianolic acid a, Sal-A）的关键中间体。本文提出了一种简单、高效、可扩展的全合成Sal-F的途径。Sal-F的全合成仅需5步，总收率高达45%。这种合成技术是从廉价材料开始的，其中避免了一些令人不快的反应物，如Br2和n-BuLi。更重要的是，该方案也适用于19克规模的合成。该方案对sala的合成至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An Improved, Concise, and Scalable Approach for the Total Synthesis of Salvianolic Acid F

查看原文本刊更多论文

An Improved, Concise, and Scalable Approach for the Total Synthesis of Salvianolic Acid F

Salvianolic acid F (Sal-F) is one of the most active components in the traditional Chinese medicine Danshen, and is a key intermediate in the synthesis of salvianolic acid A (Sal-A). In this paper, a simple, efficient, and scalable route for the total synthesis of Sal-F was developed. The total synthesis of Sal-F was done through only 5 steps with high overall yield (45%). This synthetic technology was started from inexpensive materials, in which, some unpleasant reactants such as Br₂ and n-BuLi were avoided. More importantly, this protocol was also applicable for 19 gram-scale synthesis. This protocol is crucial for the synthesis of Sal-A.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.