头颈部伯克氏菌感染：街区的新房客

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-07-21 DOI:10.1016/j.oooo.2025.04.016

Irit Allon

{"title":"头颈部伯克氏菌感染：街区的新房客","authors":"Irit Allon","doi":"10.1016/j.oooo.2025.04.016","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Burkholderia is a less familiar family of gram-negative bacteria with potential to harm human, usually reported in immunocompromised patients. The aims of this study are to present a case report of Burkholderia infection in the head and neck area and to discuss the clinical and histopathological features of Burkholderia infections in general in the head and neck region including treatment options.</div></div><div><h3>Methods</h3><div>A comprehensive English literature analysis between years 1995 and 2022, which were included in the current review.</div></div><div><h3>Results</h3><div>A total of 29 patients, M:F ratio 1.07. The age ranged from 5 to 77 years with an average of 41.4 + 17.4 years. The most common infection site was the lower neck. Most of the patients developed an abscess. Systemic presentation mainly included fever. Overall, 55.17% of the patients had some form of immunosuppression. The most common specie was <em>Burkholderia pseudomallei</em>. Five of the patients had a combined infections. Patients received 1-12 types of antibiotics. A total of 26 patients required surgical treatment in addition to antibiotics. A total of 27 patients recovered, while 2 patients died from the infection. The histopathological spectrum included: Necrotizing granuloma, chronic or acute inflammation and necrotizing fasciitis.</div></div><div><h3>Conclusion</h3><div>This study consolidates for the first time all cases of Burkholderia infections, a relatively unknown type of bacterium in the head and neck area. This is a rare phenomenon, with patients that are usually immunosuppressed, and the treatment is usually a long-term combination of surgery and medication. The attending clinician should be familiar with the pathogen, the clinical signs of infection, and the patient’s treatment options. This bacterium can manifest as an abscess, acute and chronic inflammation, and necrotizing granulomas. The prognosis is excellent when an early diagnosis is made and appropriate treatment administered. Burkholderia infection should be considered in the differential diagnosis of abscesses and granulomas with necrosis in the head and neck area.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e72"},"PeriodicalIF":1.9000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Burkholderia infections in the head and neck: a new tenant in the block\",\"authors\":\"Irit Allon\",\"doi\":\"10.1016/j.oooo.2025.04.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Burkholderia is a less familiar family of gram-negative bacteria with potential to harm human, usually reported in immunocompromised patients. The aims of this study are to present a case report of Burkholderia infection in the head and neck area and to discuss the clinical and histopathological features of Burkholderia infections in general in the head and neck region including treatment options.</div></div><div><h3>Methods</h3><div>A comprehensive English literature analysis between years 1995 and 2022, which were included in the current review.</div></div><div><h3>Results</h3><div>A total of 29 patients, M:F ratio 1.07. The age ranged from 5 to 77 years with an average of 41.4 + 17.4 years. The most common infection site was the lower neck. Most of the patients developed an abscess. Systemic presentation mainly included fever. Overall, 55.17% of the patients had some form of immunosuppression. The most common specie was <em>Burkholderia pseudomallei</em>. Five of the patients had a combined infections. Patients received 1-12 types of antibiotics. A total of 26 patients required surgical treatment in addition to antibiotics. A total of 27 patients recovered, while 2 patients died from the infection. The histopathological spectrum included: Necrotizing granuloma, chronic or acute inflammation and necrotizing fasciitis.</div></div><div><h3>Conclusion</h3><div>This study consolidates for the first time all cases of Burkholderia infections, a relatively unknown type of bacterium in the head and neck area. This is a rare phenomenon, with patients that are usually immunosuppressed, and the treatment is usually a long-term combination of surgery and medication. The attending clinician should be familiar with the pathogen, the clinical signs of infection, and the patient’s treatment options. This bacterium can manifest as an abscess, acute and chronic inflammation, and necrotizing granulomas. The prognosis is excellent when an early diagnosis is made and appropriate treatment administered. Burkholderia infection should be considered in the differential diagnosis of abscesses and granulomas with necrosis in the head and neck area.</div></div>\",\"PeriodicalId\":49010,\"journal\":{\"name\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"volume\":\"140 3\",\"pages\":\"Page e72\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212440325008855\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440325008855","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

伯克霍尔德氏菌是一种不太为人所知的革兰氏阴性菌，对人类有潜在的危害，通常在免疫功能低下的患者中报道。本研究的目的是报告头颈部伯克氏菌感染的病例，并讨论头颈部伯克氏菌感染的临床和组织病理学特征，包括治疗方案。方法对纳入本综述的1995 ~ 2022年英文文献进行综合分析。结果共29例患者，M:F比值为1.07。年龄5 ~ 77岁，平均41.4岁 + 17.4岁。最常见的感染部位是下颈部。大多数病人都出现了脓肿。全身表现主要为发热。总体而言，55.17%的患者存在某种形式的免疫抑制。最常见的菌种是假马利氏伯克霍尔德菌。其中5名患者合并感染。患者接受1-12种抗生素治疗。除抗生素外，共有26例患者需要手术治疗。27例患者康复，2例患者死亡。组织病理学表现包括：坏死性肉芽肿、慢性或急性炎症、坏死性筋膜炎。结论本研究首次合并了所有的伯克氏菌感染病例，这是头颈部一种相对未知的细菌类型。这是一种罕见的现象，患者通常免疫抑制，治疗通常是手术和药物的长期结合。主治医生应熟悉病原体、感染的临床症状和患者的治疗方案。这种细菌可以表现为脓肿、急性和慢性炎症以及坏死性肉芽肿。早期诊断并给予适当治疗，预后良好。在头颈部脓肿和肉芽肿伴坏死的鉴别诊断中应考虑伯克氏菌感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Burkholderia infections in the head and neck: a new tenant in the block

Introduction

Burkholderia is a less familiar family of gram-negative bacteria with potential to harm human, usually reported in immunocompromised patients. The aims of this study are to present a case report of Burkholderia infection in the head and neck area and to discuss the clinical and histopathological features of Burkholderia infections in general in the head and neck region including treatment options.

Methods

A comprehensive English literature analysis between years 1995 and 2022, which were included in the current review.

Results

A total of 29 patients, M:F ratio 1.07. The age ranged from 5 to 77 years with an average of 41.4 + 17.4 years. The most common infection site was the lower neck. Most of the patients developed an abscess. Systemic presentation mainly included fever. Overall, 55.17% of the patients had some form of immunosuppression. The most common specie was Burkholderia pseudomallei. Five of the patients had a combined infections. Patients received 1-12 types of antibiotics. A total of 26 patients required surgical treatment in addition to antibiotics. A total of 27 patients recovered, while 2 patients died from the infection. The histopathological spectrum included: Necrotizing granuloma, chronic or acute inflammation and necrotizing fasciitis.

Conclusion

This study consolidates for the first time all cases of Burkholderia infections, a relatively unknown type of bacterium in the head and neck area. This is a rare phenomenon, with patients that are usually immunosuppressed, and the treatment is usually a long-term combination of surgery and medication. The attending clinician should be familiar with the pathogen, the clinical signs of infection, and the patient’s treatment options. This bacterium can manifest as an abscess, acute and chronic inflammation, and necrotizing granulomas. The prognosis is excellent when an early diagnosis is made and appropriate treatment administered. Burkholderia infection should be considered in the differential diagnosis of abscesses and granulomas with necrosis in the head and neck area.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.