用于硼中子俘获治疗的硼纳米药物

IF 1.8 3区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR
Jiaxin Wan , Linwen Lv , Yanan Chang , Juan Li , Gengmei Xing , Kui Chen
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引用次数: 0

摘要

硼中子俘获疗法(BNCT)是一种很有前景的恶性肿瘤治疗方法,它能够通过单细胞水平的核反应选择性地杀死肿瘤细胞,而不会损伤周围的正常细胞。近年来,随着纳米递送系统的快速发展,硼纳米药物提高了肿瘤内硼的递送效率,增强了BNCT的治疗效果。本文首先回顾了临床批准的硼药物及其局限性,然后重点介绍了不同硼纳米药物的设计策略。最后讨论了无载体硼纳米药物和利用载体硼纳米药物的优点和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Boron nanodrugs for boron neutron capture therapy

Boron nanodrugs for boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra-tumor boron delivery and enhanced the therapeutic efficacy of BNCT. In this paper, we first review the clinically approved boron drugs and their limitations, followed by highlighting the design strategies of different boron nanodrugs. The discussion conclude with the advantages and limitations of carrier-free boron nanodrugs and boron nanodrugs utilizing carriers.
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来源期刊
Applied Radiation and Isotopes
Applied Radiation and Isotopes 工程技术-核科学技术
CiteScore
3.00
自引率
12.50%
发文量
406
审稿时长
13.5 months
期刊介绍: Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.
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