Jiaxin Wan , Linwen Lv , Yanan Chang , Juan Li , Gengmei Xing , Kui Chen
{"title":"用于硼中子俘获治疗的硼纳米药物","authors":"Jiaxin Wan , Linwen Lv , Yanan Chang , Juan Li , Gengmei Xing , Kui Chen","doi":"10.1016/j.apradiso.2025.112044","DOIUrl":null,"url":null,"abstract":"<div><div>Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra-tumor boron delivery and enhanced the therapeutic efficacy of BNCT. In this paper, we first review the clinically approved boron drugs and their limitations, followed by highlighting the design strategies of different boron nanodrugs. The discussion conclude with the advantages and limitations of carrier-free boron nanodrugs and boron nanodrugs utilizing carriers.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112044"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Boron nanodrugs for boron neutron capture therapy\",\"authors\":\"Jiaxin Wan , Linwen Lv , Yanan Chang , Juan Li , Gengmei Xing , Kui Chen\",\"doi\":\"10.1016/j.apradiso.2025.112044\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra-tumor boron delivery and enhanced the therapeutic efficacy of BNCT. In this paper, we first review the clinically approved boron drugs and their limitations, followed by highlighting the design strategies of different boron nanodrugs. The discussion conclude with the advantages and limitations of carrier-free boron nanodrugs and boron nanodrugs utilizing carriers.</div></div>\",\"PeriodicalId\":8096,\"journal\":{\"name\":\"Applied Radiation and Isotopes\",\"volume\":\"225 \",\"pages\":\"Article 112044\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Radiation and Isotopes\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0969804325003896\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Radiation and Isotopes","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969804325003896","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra-tumor boron delivery and enhanced the therapeutic efficacy of BNCT. In this paper, we first review the clinically approved boron drugs and their limitations, followed by highlighting the design strategies of different boron nanodrugs. The discussion conclude with the advantages and limitations of carrier-free boron nanodrugs and boron nanodrugs utilizing carriers.
期刊介绍:
Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria.
Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.