（4 + 3）烯酮系固吲哚与α-烷基亚胺琥珀酰亚胺的环接：七元氮平[3,2,1-hi]吲哚支架的制备

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-07-21 DOI:10.1039/d5cc02885j

Mohammad Saim Raza, K. M. Roshani, Rama Krishna Peddinti

{"title":"（4 + 3）烯酮系固吲哚与α-烷基亚胺琥珀酰亚胺的环接：七元氮平[3,2,1-hi]吲哚支架的制备","authors":"Mohammad Saim Raza, K. M. Roshani, Rama Krishna Peddinti","doi":"10.1039/d5cc02885j","DOIUrl":null,"url":null,"abstract":"We have developed a straightforward synthesis of azepino[3,2,1-hi]indole architectures having four contiguous chiral carbons as single diastereomers. This metal-free protocol between indole-enones and alkylidene succinimides proceeds efficiently under ambient conditions, demonstrating a broad scope in good to excellent yields. The feasibility of the current methodology was illustrated by one-pot, gram-scale synthesis and further modifications.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"675 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"(4 + 3) Annulation of Enone-Tethered Indoles with α-Alkylidene Succinimides: Access to Seven-Membered Azepino[3,2,1-hi]Indole Scaffolds\",\"authors\":\"Mohammad Saim Raza, K. M. Roshani, Rama Krishna Peddinti\",\"doi\":\"10.1039/d5cc02885j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We have developed a straightforward synthesis of azepino[3,2,1-hi]indole architectures having four contiguous chiral carbons as single diastereomers. This metal-free protocol between indole-enones and alkylidene succinimides proceeds efficiently under ambient conditions, demonstrating a broad scope in good to excellent yields. The feasibility of the current methodology was illustrated by one-pot, gram-scale synthesis and further modifications.\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"675 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5cc02885j\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5cc02885j","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

我们已经开发了一种简单的合成氮平[3,2,1-hi]吲哚结构，具有四个连续的手性碳作为单个非对映体。这种在吲哚烯酮和烷基基琥珀酰亚胺之间的无金属协议在环境条件下有效地进行，显示出良好到优异的产率的广泛范围。通过一锅、克级合成和进一步改进，证明了现有方法的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

(4 + 3) Annulation of Enone-Tethered Indoles with α-Alkylidene Succinimides: Access to Seven-Membered Azepino[3,2,1-hi]Indole Scaffolds

We have developed a straightforward synthesis of azepino[3,2,1-hi]indole architectures having four contiguous chiral carbons as single diastereomers. This metal-free protocol between indole-enones and alkylidene succinimides proceeds efficiently under ambient conditions, demonstrating a broad scope in good to excellent yields. The feasibility of the current methodology was illustrated by one-pot, gram-scale synthesis and further modifications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.