外用辅酶Q10联合维生素E对原发性开角型青光眼患者模式视觉诱发电位、视野、视网膜神经节细胞层和视网膜神经纤维层厚度的影响

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-16 DOI:10.1016/j.pdpdt.2025.104720

Mahmut Dogan , Galip Ertugrul Mirza

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引用次数: 0

摘要

目的：探讨辅酶Q10+维生素E对原发性开角型青光眼（POAG）患者模式视觉诱发电位（VEP）、视野、视网膜神经节细胞层及rnfl厚度的影响。方法：选取48例POAG患者的96只眼。48只眼睛被选为研究组，另外48只眼睛被选为对照组。在基线、第6个月和第12个月，分别记录实验组48只经辅酶Q10+维生素E （Coqun®）加替洛尔+多唑胺治疗的POAG眼和对照组48只经替洛尔+多唑胺治疗的POAG眼的VEP、视野参数和光学相干断层扫描（OCT）（即rnfl）。结果：12个月后，两组患者神经节细胞层数均较基线减少（p0.05）。在对照组12个月结束时，24例（50%）患者的MD增加(p)。结论：目前，青光眼的神经保护药物研究日益增多。这些结果表明，Coqun®在POAG中给药对视网膜内层有有益的影响，从而增强视觉皮质反应（VEP改善），视野（MD减少）和保护RNFL厚度。

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Effects of topical coenzyme Q10 in conjunction with vitamin e on the pattern visual evoked potential, visual field, retinal ganglion cell layer and retinal nerve fibre layer thickness in patients with primary open-angle glaucoma

Purpose

To evaluate the effects of coenzyme Q10+vitamin E on the pattern visual evoked potential (VEP), visual field, retinal ganglion cell layer and RNFLthickness in patients with primary open-angle glaucoma (POAG).

Methods

Ninety-six eyes from forty-eight POAG patients were enrolled. Forty-eight eyes were chosen for the study group, and fellow forty-eight eyes were chosen for the control group. At baseline, 6th month, and 12th month, the VEP, visual field parameters, and optical coherence tomography (OCT) (i.e.RNFL) were recorded for the 48 POAG eyes that underwent treatment with coenzyme Q10+vitamin E (Coqun®) in addition timolol+dorzolamide in study group and for the 48 POAG eyes that were only treated with timolol+dorzolamide in control group.

Results

After 12 months, ganglion cell layer of both groups were decreased when compared to baseline (p < 0.05). Although the decrease in the ganglion cell layer in the control group was greater. After 12 months, in control group patients VEP P100 implicit times were increased, whereas P100 amplitudes were decreased (P < 0.05) .In study group patients, VEP P100 implicit times were decreased, whereas P100 amplitudes were increased (P < 0.05) when compared to baseline. At the end of 12 months in the study group, there was no significant change in the 32 patients ( %67), and the current visual field was preserved. (p > 0.05).In the control group at the end of the12 month, 24 ( %50)patients had an increase in MD (p < 0.05). In both groups, the RNFL thickness at 12 months showed a significant decrease (p˂ 0.05) compared to baseline.

Conclusion

Currently, neuroprotective drug studies in glaucoma are increasing daily.These results suggest that Coqun® administration in POAG had a beneficial effect on the inner retinal layer with consequent enhancement of the visual cortical responses (VEP improvement),visual field (decreased MD) and protect RNFL thickness.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.