宫颈副神经节瘤恶性肿瘤的预测因素：回顾性研究。

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-07-18 DOI:10.1002/hed.28250

Garance Haw, Maxime Fieux, Anthime Flaus, Hélène Lasolle, Juliette Abeillon, Myriam Decaussin-Petrucci, Dylan Pavie, Benjamin Verillaud, Philippe Herman, Patrick Feugier, Fatima Ameur, Pierre Philouze, Françoise Borson-Chazot, Philippe Ceruse

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引用次数: 0

摘要

背景：转移性宫颈副神经节瘤（cPG）的早期预测因素缺乏。方法：这项多中心回顾性研究纳入了至少一种cPG的患者。转移性cPG的定义是组织学上是否存在淋巴结转移或远处转移。收集临床、放射学、术中、组织学和突变状态特征。应用logistic回归分析转移性cPG的预测因素。结果：纳入67例患者，对应cPG 86次；其中12.8%是转移性的。新发现的七个危险因素是：形态学成像（MRI和/或CT）出现坏死（OR = 12.36, 95% CI:[3.03-55.66]）、囊外延伸（OR = 33.42, 95% CI:[2.48-4752.00]）和病理性淋巴结（OR = 25.00, 95% CI: [3.96-276.07]）；功能成像（FDG-PET-CT）的异质性肿瘤摄取（OR = 15.5, 95% CI:[2.31-143.68]）和异常淋巴结摄取（OR = 16.5, 95% CI: [2.04-174.94]）；（OR = 34.63, 95% CI:[3.82-4602.65]）和牺牲崇高结构（OR = 75.9, 95% CI:[7.99-10230.73]）。结论：这些危险因素可以结合起来及时识别侵袭性cPG并调整治疗策略。

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Predictive Factors of Malignancy in Cervical Paragangliomas: A Retrospective Study.

Background: Early predictive factors of metastatic cervical paragangliomas (cPG) are lacking.

Methods: This multicenter retrospective study included patients with at least one cPG. Metastatic cPG were defined by the histological presence of lymph node metastases or distant metastases. Clinical, radiological, intraoperative, histological, and mutational status characteristics were collected. Predictive factors of metastatic cPG were searched using logistic regression.

Results: Sixty-seven patients were included, corresponding to 86 cPG; 12.8% of these were metastatic. The seven newly identified risk factors were: presence of necrosis (OR = 12.36, 95% CI: [3.03-55.66]), extracapsular extension (OR = 33.42, 95% CI: [2.48-4752.00]), and pathological lymph nodes (OR = 25.00, 95% CI: [3.96-276.07]) on morphological imaging (MRI and/or CT); heterogeneous tumor uptake (OR = 15.5, 95% CI: [2.31-143.68]) and abnormal lymph node uptake (OR = 16.5, 95% CI: [2.04-174.94]) on functional imaging (FDG-PET-CT); invasion of adjacent tissues (OR = 34.63, 95% CI: [3.82-4602.65]) and sacrifice of noble structures (OR = 75.9, 95% CI: [7.99-10230.73]) in patients who underwent surgery.

Conclusion: These risk factors could be combined to promptly identify aggressive cPG and adapt therapeutic strategy.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.