Prediction Model for Detrusor Underactivity via Noninvasive Clinical Parameters in Men With Benign Prostatic Hyperplasia.

Objective: To develop a clinical prediction model for detrusor underactivity (DU) in patients with benign prostatic hyperplasia (BPH).

Methods: A retrospective review was conducted on 546 individuals with BPH who had undergone urodynamic testing between January 2012 and May 2022. The bladder contractility index (BCI) was assessed using a pressure-flow study (PFS). Patients were categorized into DU (BCI <100, n = 196) and non-DU (BCI ≥100, n = 350) groups. Univariate logistic regression was initially performed to identify potential DU-related factors, followed by multivariate analysis to determine independent risk factors.

Results: A predictive model for DU in patients with BPH was developed using the coefficient of these independent risk factors. Among the 546 cases, 196 (35.9%) were diagnosed with DU. Older age, smaller prostate volume, lower urgency symptom score, lower incomplete emptying symptom score, higher straining symptom score, and lower maximum flow rate (Qmax) were identified as independent predictors of DU in patients with BPH. The model demonstrated an area under the curve of 0.78 (95% CI, 0.74-0.82), with internal validation yielding 0.75 (95% CI, 0.74-0.75).

Conclusion: We developed a predictive model that effectively estimates the DU probability in patients with BPH without requiring invasive pressure-flow study.