烟曲霉J2-22-1中新的细胞毒性对羟基苯甲酸和倍半萜衍生酰胺。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-07-20 DOI:10.1080/14786419.2025.2534684

Wenjie Han, Huiying Liu, Meng Ren, Nanxin Gong, Xupei Men, Yurun Wang, Taoshuai Cao, Xiaomei Song, Hongliang Tang, Xiaolong Zhao, Jun Zhang, Du-Qiang Luo

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引用次数: 0

摘要

从荒漠土壤真菌烟曲霉J2-22-1中分离到对羟基苯甲酸和倍半萜两种新酰胺（1-2）和一种已知倍半萜(3)。通过光谱分析获得结构表征，通过比较ECD光谱确认绝对构型。这些化合物在MCF-7、SGC-7901、MGC-803和HepG2四种人类肿瘤模型上的抗癌潜力进行了评估。值得注意的是，所有化合物均显示出广谱细胞毒活性（IC50值为20.17 ~ 94.83 μM）。

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New cytotoxic p-hydroxybenzoic acid and sesquiterpene-derived amides from Aspergillus fumigatus J2-22-1.

Two new amides (1-2) derived from p-hydroxybenzoic acid and sesquiterpene, respectively, along with one known sesquiterpene (3), were isolated from the desert soil-derived fungus Aspergillus fumigatus J2-22-1. Structural characterisation was achieved through spectroscopic analysis, with absolute configurations confirmed via comparative ECD spectra. The anticancer potential of these compounds was evaluated against four human tumour models: MCF-7, SGC-7901, MGC-803, and HepG2. Notably, all test compounds -displayed broad-spectrum cytotoxic activities (IC₅₀ values: 20.17-94.83 μM).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.