【撤回】抑制TLR4可保护大鼠胰岛免受脂多糖诱导的功能障碍。

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Molecular medicine reports Pub Date : 2025-10-01 Epub Date: 2025-07-19 DOI:10.3892/mmr.2025.13622
Xiao Wang, Qin Min Ge, Fan Bian, Yan Dong, Chun Mei Huang
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引用次数: 0

摘要

在上述论文发表后,一位关心的读者引起了编辑的注意,关于809页图3A中显示的较低的两个流式细胞术图(即“抗TLR4+LPS”和“TLR4 - shRNA+LPS”实验的图),这些图似乎显示了相似的点组,如果这些实验在不同的实验条件下离散地进行,则不会预料到这一点。表明这些实验的执行方式或结果的输出方式存在根本缺陷。《分子医学报告》的编辑已经决定,由于对所呈现的数据缺乏信心,这篇论文应该从杂志上撤回。作者被要求对这些担忧作出解释,但编辑部没有收到答复。对于由此给读者带来的不便,本刊编辑深表歉意。[分子医学报道]15:805‑812,2017;DOI: 10.3892 / mmr.2016.6097]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Retracted] Inhibition of TLR4 protects rat islets against lipopolysaccharide‑induced dysfunction.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the lower two flow cytometric plots shown in Fig. 3A on p. 809 (namely, the plots for the 'anti‑TLR4+LPS' and 'TLR4‑shRNA+LPS' experiments), these appeared to show similar groupings of dots, which would not have been anticipated if these experiments had been performed discretely under different experimental conditions, suggesting a fundamental flaw either in the way in which these experiments were performed, or in how the results were outputted. The Editor of Molecular Medicine Reports has decided that this paper should be retracted from the Journal on account of a lack of confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 15: 805‑812, 2017; DOI: 10.3892/mmr.2016.6097].

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来源期刊
Molecular medicine reports
Molecular medicine reports 医学-病理学
CiteScore
7.60
自引率
0.00%
发文量
321
审稿时长
1.5 months
期刊介绍: Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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