早期非小细胞肺癌术后进展风险的协作评估:一个强大的联合学习模型。

IF 3.5 2区 医学 Q2 ONCOLOGY
Yu Liu, Xiaobei Duan, Xiaojuan Chen, Kunwei Li, Qiong Li, Ke Liu, Wansheng Long, Huan Lin, Bao Feng, Xiangmeng Chen
{"title":"早期非小细胞肺癌术后进展风险的协作评估:一个强大的联合学习模型。","authors":"Yu Liu, Xiaobei Duan, Xiaojuan Chen, Kunwei Li, Qiong Li, Ke Liu, Wansheng Long, Huan Lin, Bao Feng, Xiangmeng Chen","doi":"10.1186/s40644-025-00911-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>While the TNM staging system provides valuable insights into the extent of disease, predicting postoperative progression in early-stage non-small cell lung cancer (NSCLC) remains a significant challenge. An effective bioimaging prognostic marker for early-stage NSCLC, powered by artificial intelligence, could greatly assist clinicians in making informed treatment decisions.</p><p><strong>Methods: </strong>A total of 926 patients from four centers (A, B, C, and D) with histologically confirmed stage I or II solid non-small cell lung cancer (NSCLC) who underwent surgical resection were retrospectively reviewed. In this study, we propose a robust federated learning model (RFed) designed to predict the risk of postoperative progression in early-stage NSCLC patients. The diagnostic efficiency of the RFed model was evaluated using the area under the curve (AUC) and Decision Curve Analysis (DCA). Additionally, the model's performance was further validated through Kaplan-Meier survival analysis, with statistical significance assessed using the log-rank test. Finally, the robustness, generalizability, and interpretability of the RFed model were comprehensively evaluated to confirm its clinical applicability.</p><p><strong>Results: </strong>Experimental results demonstrated the superior performance of the RFed model. Specifically, RFed achieved AUC values of 0.936, 0.861, 0.925, and 0.970 on the test sets from the four centers. DCA further revealed that RFed provided a greater net benefit compared to the clinical model across a threshold probability range of 0.02 to 0.99. Moreover, Kaplan-Meier curves showed improved discrimination between high-risk and low-risk groups when compared to other models, highlighting its enhanced predictive capability.</p><p><strong>Conclusions: </strong>The RFed model demonstrates significant effectiveness in predicting the risk of postoperative progression in early-stage NSCLC patients. Its clinical application value lies in its potential to enhance stratified management and support the development of precise treatment strategies for this patient population.</p>","PeriodicalId":9548,"journal":{"name":"Cancer Imaging","volume":"25 1","pages":"92"},"PeriodicalIF":3.5000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273366/pdf/","citationCount":"0","resultStr":"{\"title\":\"Collaborative assessment of the risk of postoperative progression in early-stage non-small cell lung cancer: a robust federated learning model.\",\"authors\":\"Yu Liu, Xiaobei Duan, Xiaojuan Chen, Kunwei Li, Qiong Li, Ke Liu, Wansheng Long, Huan Lin, Bao Feng, Xiangmeng Chen\",\"doi\":\"10.1186/s40644-025-00911-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>While the TNM staging system provides valuable insights into the extent of disease, predicting postoperative progression in early-stage non-small cell lung cancer (NSCLC) remains a significant challenge. An effective bioimaging prognostic marker for early-stage NSCLC, powered by artificial intelligence, could greatly assist clinicians in making informed treatment decisions.</p><p><strong>Methods: </strong>A total of 926 patients from four centers (A, B, C, and D) with histologically confirmed stage I or II solid non-small cell lung cancer (NSCLC) who underwent surgical resection were retrospectively reviewed. In this study, we propose a robust federated learning model (RFed) designed to predict the risk of postoperative progression in early-stage NSCLC patients. The diagnostic efficiency of the RFed model was evaluated using the area under the curve (AUC) and Decision Curve Analysis (DCA). Additionally, the model's performance was further validated through Kaplan-Meier survival analysis, with statistical significance assessed using the log-rank test. Finally, the robustness, generalizability, and interpretability of the RFed model were comprehensively evaluated to confirm its clinical applicability.</p><p><strong>Results: </strong>Experimental results demonstrated the superior performance of the RFed model. Specifically, RFed achieved AUC values of 0.936, 0.861, 0.925, and 0.970 on the test sets from the four centers. DCA further revealed that RFed provided a greater net benefit compared to the clinical model across a threshold probability range of 0.02 to 0.99. Moreover, Kaplan-Meier curves showed improved discrimination between high-risk and low-risk groups when compared to other models, highlighting its enhanced predictive capability.</p><p><strong>Conclusions: </strong>The RFed model demonstrates significant effectiveness in predicting the risk of postoperative progression in early-stage NSCLC patients. Its clinical application value lies in its potential to enhance stratified management and support the development of precise treatment strategies for this patient population.</p>\",\"PeriodicalId\":9548,\"journal\":{\"name\":\"Cancer Imaging\",\"volume\":\"25 1\",\"pages\":\"92\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273366/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40644-025-00911-y\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40644-025-00911-y","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:虽然TNM分期系统为疾病程度提供了有价值的见解,但预测早期非小细胞肺癌(NSCLC)的术后进展仍然是一个重大挑战。一种由人工智能驱动的早期非小细胞肺癌的有效生物成像预后标志物,可以极大地帮助临床医生做出明智的治疗决策。方法:回顾性分析4个中心(A、B、C、D)共926例组织学证实的I期或II期实体性非小细胞肺癌(NSCLC)行手术切除的患者。在这项研究中,我们提出了一个强大的联邦学习模型(RFed),旨在预测早期NSCLC患者术后进展的风险。采用曲线下面积(AUC)和决策曲线分析(DCA)评价RFed模型的诊断效率。此外,通过Kaplan-Meier生存分析进一步验证模型的性能,并使用log-rank检验评估统计学显著性。最后,对RFed模型的稳健性、通用性和可解释性进行综合评价,以确认其临床适用性。结果:实验结果证明了RFed模型的优越性能。具体而言,RFed在四个中心的测试集上的AUC值分别为0.936、0.861、0.925和0.970。DCA进一步显示,与临床模型相比,RFed在阈值概率范围为0.02至0.99之间提供了更大的净收益。此外,Kaplan-Meier曲线与其他模型相比,对高风险和低风险群体的区分能力有所提高,突出了其增强的预测能力。结论:RFed模型在预测早期NSCLC患者术后进展风险方面具有显著的有效性。它的临床应用价值在于它有可能加强分层管理,并支持对这一患者群体制定精确的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Collaborative assessment of the risk of postoperative progression in early-stage non-small cell lung cancer: a robust federated learning model.

Background: While the TNM staging system provides valuable insights into the extent of disease, predicting postoperative progression in early-stage non-small cell lung cancer (NSCLC) remains a significant challenge. An effective bioimaging prognostic marker for early-stage NSCLC, powered by artificial intelligence, could greatly assist clinicians in making informed treatment decisions.

Methods: A total of 926 patients from four centers (A, B, C, and D) with histologically confirmed stage I or II solid non-small cell lung cancer (NSCLC) who underwent surgical resection were retrospectively reviewed. In this study, we propose a robust federated learning model (RFed) designed to predict the risk of postoperative progression in early-stage NSCLC patients. The diagnostic efficiency of the RFed model was evaluated using the area under the curve (AUC) and Decision Curve Analysis (DCA). Additionally, the model's performance was further validated through Kaplan-Meier survival analysis, with statistical significance assessed using the log-rank test. Finally, the robustness, generalizability, and interpretability of the RFed model were comprehensively evaluated to confirm its clinical applicability.

Results: Experimental results demonstrated the superior performance of the RFed model. Specifically, RFed achieved AUC values of 0.936, 0.861, 0.925, and 0.970 on the test sets from the four centers. DCA further revealed that RFed provided a greater net benefit compared to the clinical model across a threshold probability range of 0.02 to 0.99. Moreover, Kaplan-Meier curves showed improved discrimination between high-risk and low-risk groups when compared to other models, highlighting its enhanced predictive capability.

Conclusions: The RFed model demonstrates significant effectiveness in predicting the risk of postoperative progression in early-stage NSCLC patients. Its clinical application value lies in its potential to enhance stratified management and support the development of precise treatment strategies for this patient population.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cancer Imaging
Cancer Imaging ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
7.00
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Cancer Imaging is an open access, peer-reviewed journal publishing original articles, reviews and editorials written by expert international radiologists working in oncology. The journal encompasses CT, MR, PET, ultrasound, radionuclide and multimodal imaging in all kinds of malignant tumours, plus new developments, techniques and innovations. Topics of interest include: Breast Imaging Chest Complications of treatment Ear, Nose & Throat Gastrointestinal Hepatobiliary & Pancreatic Imaging biomarkers Interventional Lymphoma Measurement of tumour response Molecular functional imaging Musculoskeletal Neuro oncology Nuclear Medicine Paediatric.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信