人葡萄膜黑色素瘤赖氨酸氧化酶表达及血管床分析。

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-01 Epub Date: 2025-07-19 DOI:10.1007/s10517-025-06441-8

A Yu Shatruk, N P Bgatova, N V Kononova, A V Eremina, A N Trunov, V V Chernykh, Iu S Taskaeva

{"title":"人葡萄膜黑色素瘤赖氨酸氧化酶表达及血管床分析。","authors":"A Yu Shatruk, N P Bgatova, N V Kononova, A V Eremina, A N Trunov, V V Chernykh, Iu S Taskaeva","doi":"10.1007/s10517-025-06441-8","DOIUrl":null,"url":null,"abstract":"The expression of lysyl oxidase (LOX) was assessed using immunohistochemical staining in tissue samples from the postequatorial region of the choroid and uveal melanoma obtained from human eyes enucleated for medical reasons (n = 15). It was found that LOX expression was higher in the tumor tissue. Significantly increased density of blood vessels was observed in the intratumoral region compared to the postequatorial region of the choroid. Elevated LOX expression can be associated with the formation of small blood vessels in the tumor, likely due to angiogenesis activation in human uveal melanoma.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"64-68"},"PeriodicalIF":0.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of Lysyl Oxidase Expression and Vascular Bed in Human Uveal Melanoma.\",\"authors\":\"A Yu Shatruk, N P Bgatova, N V Kononova, A V Eremina, A N Trunov, V V Chernykh, Iu S Taskaeva\",\"doi\":\"10.1007/s10517-025-06441-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The expression of lysyl oxidase (LOX) was assessed using immunohistochemical staining in tissue samples from the postequatorial region of the choroid and uveal melanoma obtained from human eyes enucleated for medical reasons (n = 15). It was found that LOX expression was higher in the tumor tissue. Significantly increased density of blood vessels was observed in the intratumoral region compared to the postequatorial region of the choroid. Elevated LOX expression can be associated with the formation of small blood vessels in the tumor, likely due to angiogenesis activation in human uveal melanoma.\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"64-68\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06441-8\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06441-8","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

采用免疫组化染色法对因医学原因摘除的人眼脉络膜和葡萄膜黑色素瘤的后叶区组织样本进行赖氨酸氧化酶（LOX）的表达评估（n = 15）。发现LOX在肿瘤组织中表达较高。与脉络膜后区相比，肿瘤内血管密度明显增加。升高的LOX表达可能与肿瘤中小血管的形成有关，可能是由于人葡萄膜黑色素瘤的血管生成激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Analysis of Lysyl Oxidase Expression and Vascular Bed in Human Uveal Melanoma.

The expression of lysyl oxidase (LOX) was assessed using immunohistochemical staining in tissue samples from the postequatorial region of the choroid and uveal melanoma obtained from human eyes enucleated for medical reasons (n = 15). It was found that LOX expression was higher in the tumor tissue. Significantly increased density of blood vessels was observed in the intratumoral region compared to the postequatorial region of the choroid. Elevated LOX expression can be associated with the formation of small blood vessels in the tumor, likely due to angiogenesis activation in human uveal melanoma.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.