The mechanism underlying the association between ABO blood groups and allergic diseases: an evidence-based systematic review.

This systematic review investigates the connections between ABO blood groups and allergic diseases by analyzing the existing literature to uncover underlying immunological mechanisms. Our search of PubMed, Google Scholar, and the Cochrane Database identified 35 relevant studies, with 10 articles meeting our inclusion criteria. Results suggest that blood group antigens significantly influence immune responses through interactions with immunoglobulin E (IgE) and variations in cytokine profiles. This review highlights the impact of blood group antigens on IgE and cytokine profiles, the relationship between blood group types and allergic disease susceptibility, and the role of gut microbiota in allergy development. The evidence indicates that immunological mechanisms involving IgE antibodies and cytokine signaling play a crucial role in mediating the relationship between blood groups and allergies. Our findings underscore the importance of further research into the immunological pathways linking blood groups to allergic diseases, potentially informing the development of personalized treatments and preventative measures.