重新评估过敏反应后特异性免疫球蛋白E测定的时机。

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i4.1329
Young-Il Koh, Da Woon Sim
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引用次数: 0

摘要

过敏期定义为全身过敏反应后3-6周,皮肤试验结果为阴性。因此,大多数指南建议医生应在立即过敏反应后6周进行皮肤试验。然而,体外试验,包括血清特异性免疫球蛋白E (IgE)测量,通常被认为不受无能期的影响。在这里,我们报告了一例患者,最初头孢氯特异性IgE阴性,但在确诊头孢氯过敏后立即进行检测,在过敏期消退后,反应后8周,结果转为阳性。对于临床强烈怀疑有药物性过敏反应的患者,即使初始结果为阴性,也应在过敏期后重复体外试验。需要进一步的研究来评估免疫cap值是否与皮试反应性相似,表现出显著的短期变异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reevaluating the timing of specific immunoglobulin E measurement after anaphylaxis.

The anergic period is defined as a period of around 3-6 weeks following a systemic allergic reaction when skin test results are negative. Therefore, most guidelines recommend that physicians should conduct skin test 6 weeks after an immediate hypersensitivity reaction. However, in vitro tests, including serum-specific immunoglobulin E (IgE) measurement, are generally deemed unaffected by the anergic period. Here, we present a case of a patient with initial cefaclor-specific IgE negativity, but when tested immediately after confirmed anaphylaxis to cefaclor, the results converted to positive after the resolution of the anergic period, 8 weeks post reaction. In patients with a strong clinical suspicion of drug-induced anaphylaxis, repeating in vitro tests after the anergic period may be warranted, even if the initial results are negative. Further investigation is needed to assess whether ImmunoCAP values, similar to skin test reactivity, exhibit significant short-term variability.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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