Vanessa C C Rodrigues, Marcelo C M Fonseca, Dirceu Solé, Adiana Sanudo, Mauro B Morais
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In the initial management, the prescription rates of formulas based on extensively hydrolyzed protein and amino acid were 81.7% and 14.6% for Case 1 and 32.7% and 65.4% for Case 2 (p < 0.001); the percentages of answers for prescriptions of drugs or probiotics were 8.3% and 12.1% in cases 1 and 2 (p < 0.001); and requests for laboratory tests were 12.3% and 37.7 % (p = 0.016). The oral food challenge (OFC) test for the diagnosis of non-IgE-GI-CMPA was indicated by 55.1% and 42.7% of the physicians in cases 1 and 2 (p < 0.001). The OFC test was chosen to assess tolerance development by 92% of the interviewees. Performing the diagnostic OFC (D-OFC) test was positively associated with having board certification in pediatric gastroenterology and < 20 years of professional experience and negatively associated with using baked foods as a protein source in the oral tolerance OFC test.</p><p><strong>Conclusions: </strong>Most interviewees followed the guidelines regarding prescribing an elimination diet; however, many should include the OFC test in diagnosing infants with non-IgE-GI-CMPA. Not performing the D-OFC may have negative consequences on patients and on the public healthcare system.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"68-77"},"PeriodicalIF":2.1000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Real-life management of gastrointestinal cow's milk protein allergy in Brazilian infants.\",\"authors\":\"Vanessa C C Rodrigues, Marcelo C M Fonseca, Dirceu Solé, Adiana Sanudo, Mauro B Morais\",\"doi\":\"10.15586/aei.v53i4.1323\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate physicians' management of non-immunoglobulin E-mediated gastrointestinal cow's milk protein allergy (non-IgE-GI-CMPA) in Brazilian infants.</p><p><strong>Methods: </strong>A total of 447 physicians from all the regions of Brazil answered an online questionnaire concerning their management of formula-fed infants with mild-to-moderate (Case 1) or severe (Case 2) clinical manifestations of non-IgE-GI-CMPA.</p><p><strong>Results: </strong>In total, 95.3% and 86.0% of the interviewed physicians in cases 1 and 2 prescribed a cow's milk elimination diet (p < 0.001). 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引用次数: 0
摘要
目的:评价巴西婴儿对非免疫球蛋白e介导的胃肠道牛奶蛋白过敏(non-IgE-GI-CMPA)的处理。方法:来自巴西所有地区的447名医生回答了一份在线问卷,内容涉及他们对患有轻度至中度(病例1)或重度(病例2)非ige - gi - cmpa临床表现的配方喂养婴儿的管理。结果:病例1和病例2中分别有95.3%和86.0%的受访医师给患者开了牛奶消除日粮(p < 0.001)。在初始管理中,病例1的广谱水解蛋白和氨基酸配方的处方率分别为81.7%和14.6%,病例2的处方率分别为32.7%和65.4% (p < 0.001);病例1和病例2的药物或益生菌处方回答率分别为8.3%和12.1% (p < 0.001);要求实验室检查的分别为12.3%和37.7% (p = 0.016)。病例1和病例2中分别有55.1%和42.7%的医生认为口服食物激发(OFC)试验可诊断非ige - gi - cmpa (p < 0.001)。92%的受访者选择OFC测试来评估耐受性的发展。进行诊断性OFC (D-OFC)测试与拥有儿科胃肠病学委员会认证和< 20年专业经验呈正相关,与在口服耐受OFC测试中使用烘焙食品作为蛋白质来源负相关。结论:大多数受访者遵循关于开具消除饮食的指南;然而,在诊断非ige - gi - cmpa的婴儿时,许多人应该包括OFC测试。不履行D-OFC可能会对患者和公共医疗保健系统产生负面影响。
Real-life management of gastrointestinal cow's milk protein allergy in Brazilian infants.
Objective: To evaluate physicians' management of non-immunoglobulin E-mediated gastrointestinal cow's milk protein allergy (non-IgE-GI-CMPA) in Brazilian infants.
Methods: A total of 447 physicians from all the regions of Brazil answered an online questionnaire concerning their management of formula-fed infants with mild-to-moderate (Case 1) or severe (Case 2) clinical manifestations of non-IgE-GI-CMPA.
Results: In total, 95.3% and 86.0% of the interviewed physicians in cases 1 and 2 prescribed a cow's milk elimination diet (p < 0.001). In the initial management, the prescription rates of formulas based on extensively hydrolyzed protein and amino acid were 81.7% and 14.6% for Case 1 and 32.7% and 65.4% for Case 2 (p < 0.001); the percentages of answers for prescriptions of drugs or probiotics were 8.3% and 12.1% in cases 1 and 2 (p < 0.001); and requests for laboratory tests were 12.3% and 37.7 % (p = 0.016). The oral food challenge (OFC) test for the diagnosis of non-IgE-GI-CMPA was indicated by 55.1% and 42.7% of the physicians in cases 1 and 2 (p < 0.001). The OFC test was chosen to assess tolerance development by 92% of the interviewees. Performing the diagnostic OFC (D-OFC) test was positively associated with having board certification in pediatric gastroenterology and < 20 years of professional experience and negatively associated with using baked foods as a protein source in the oral tolerance OFC test.
Conclusions: Most interviewees followed the guidelines regarding prescribing an elimination diet; however, many should include the OFC test in diagnosing infants with non-IgE-GI-CMPA. Not performing the D-OFC may have negative consequences on patients and on the public healthcare system.
期刊介绍:
Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.