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化学蛋白质组学显示橙皮苷和橙皮素是akr11.1 /2抑制剂，具有化学增敏作用

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chemical Communications Pub Date : 2025-08-04 DOI:10.1039/d5cc02907d
Lijun Chen , Yuanyuan Zhou , Yiyun Geng , Jianjia Liang , Hongyue Ma , Lu Ran , Jingyuan Xu , Zhangshuang Deng , Yiqing Zhou
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引用次数: 0

摘要

通过化学蛋白质组学分析发现，天然黄酮橙皮苷及其苷元橙皮苷是人醛酮还原酶家族1成员C1 （AKR1C1）和AKR1C2抑制剂，从而揭示了它们在癌症治疗中的化学增敏作用机制。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect†

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Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect†
The natural flavanone hesperidin and its aglycone hesperetin were identified as human aldo-keto reductase family 1 member C1 (AKR1C1) and AKR1C2 inhibitors via chemoproteomic profiling, which provides mechanistic insight into their chemosensitization effects in cancer therapy.
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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