壳聚糖和叶酸包覆纳米Fe2O3的制备与表征

IF 3.2 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Ravi Kant Kushwaha , Uzma Noor Shah , Vishal Sandhwar , Sakshi Pandey , Indumathi Thangavelu , AbdulAziz A. AlGhamdi , Srinivas Tadepalli
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引用次数: 0

摘要

高分子无机纳米颗粒由于其独特的性能,具有增强的抗菌和抗癌作用,已成为有前途的纳米药物。因此,本研究以万寿菊(T. erecta)提取物为载体,合成了Fe2O3和壳聚糖包被Fe2O3和叶酸纳米粒子(Fe2O3- cs - fa NPs),并对其生物效应进行了评价。通过各种表征技术对合成的NPs进行了分析。Fe2O3和Fe2O3 -CS-FA NPs的FTIR光谱显示了Fe2O3、壳聚糖和叶酸分子对应的特征峰。XRD谱图证实了Fe2O3 NPs和Fe2O3 -CS-FA NPs的成功合成,其结构为菱形面体。FESEM显示Fe2O3和Fe2O3 -CS-FA NPs均为球形结构。采用圆盘扩散法对不同病原菌的抑菌活性进行了评价,结果表明Fe2O3- cs - fa NPs的抑菌活性优于Fe2O3 NPs。在抗氧化活性方面,Fe2O3 -CS-FA NPs对DPPH的清除活性最高,优于Fe2O3 NPs。Fe2O3 -CS-FA NPs和Fe2O3 -CS-FA NPs对HCT-116人结肠癌细胞株的抗癌活性测试表明,Fe2O3 -CS-FA NPs的IC50值为10.2 μg/mL,高于Fe2O3的13.8 μg/mL。基于这项研究的结果,有一个强有力的迹象表明,Fe2O3 -CS-FA NPs作为一种非常适合先进生物医学应用的纳米材料具有巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Development and characterization of Fe2O3 nanoparticles coated with chitosan and folic acid for biomedical applications

Development and characterization of Fe2O3 nanoparticles coated with chitosan and folic acid for biomedical applications
Polymeric inorganic nanoparticles have emerged as promising nanomedicines due to their unique properties, offering enhanced antibacterial and anticancer effects. Thus, the study focus on the synthesis of Fe2O3 and Fe2O3 coated with chitosan and folic acid nanoparticles (Fe2O3-CS-FA NPs) mediated by Tagetes erecta (T. erecta) extract and assess their biological effects. The synthesized NPs are analysed by various characterisation techniques. FTIR spectroscopy of Fe2O3 and Fe2O3 -CS-FA NPs revealed characteristic peaks corresponding to Fe2O3, chitosan, and folic acid molecules. The XRD pattern confirmed the successful synthesis of Fe2O3 NPs and Fe2O3 -CS-FA NPs, indicating a rhombohedral structure. FESEM demonstrated spherical structures for both Fe2O3 and Fe2O3 -CS-FA NPs. Antimicrobial activity was assessed against various pathogens using the disk diffusion method, showing that Fe2O3-CS-FA NPs demonstrated superior antibacterial activity compared to Fe2O3 NPs. In terms of antioxidant activity, Fe2O3 -CS-FA NPs showed the highest scavenging activity against DPPH, outperforming Fe2O3 NPs. The anticancer activity of both Fe2O3 NPs and Fe2O3 -CS-FA NPs was tested against the HCT-116 human colon cancer cell line, where Fe2O3 -CS-FA NPs demonstrated greater anticancer activity with an IC50 value of 10.2 μg/mL compared to Fe2O3 at 13.8 μg/mL. Based on the findings of this research, there is a strong indication that Fe2O3 -CS-FA NPs hold significant potential as a nanomaterial well-suited for advanced biomedical applications in the industry.
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来源期刊
CiteScore
3.50
自引率
7.70%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.
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