脂肪胺与甲酰胺的快速、无溶剂和无催化剂的转酰胺反应

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-07-17 DOI:10.1016/j.tetlet.2025.155754

Jinting Li , Zihan Zhou , Yinzhe Chen , Qian Zhang

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引用次数: 0

摘要

研究了一种以甲酰胺为溶剂和反应物快速有效地进行脂肪胺n -甲酰化反应的方法。该方法不需要使用催化剂或柱层析纯化，从而简化了合成过程。该创新方法环保高效，具有良好的反应动力学，具有广泛的底物适应性和良好的官能团耐受性，也适用于某些含胺药物分子的合成或修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rapid, solvent- and catalyst-free transamidation of aliphatic amines with formamide

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Rapid, solvent- and catalyst-free transamidation of aliphatic amines with formamide

A rapid and effective transamidation process using formamide as both solvent and reactant for the N-formylation of aliphatic amines has been developed. The method does not require the use of catalysts or column chromatography for purification, thereby simplifying the synthetic procedure. This innovative method is environmentally friendly and highly efficient, exhibits excellent reaction kinetics, demonstrates broad substrate adaptability and excellent functional group tolerance, and is also suitable for synthesizing or modifying certain amine-containing drug molecules.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.