非临床数据显示，临床阶段GalNAc碱基编辑药物VERVE-102在体内有效且精确地灭活肝脏PCSK9

{"title":"非临床数据显示，临床阶段GalNAc碱基编辑药物VERVE-102在体内有效且精确地灭活肝脏PCSK9","authors":"Ellen Rohde, Richard Lee, Anne Marie Mazzola, Colin Platt, Taiji Mizoguchi, Kim Pendino, Alexandra Chadwick, Amit Khera, Scott Vafai, Sekar Kathiresan, Troy Lister, Joseph Biedenkapp","doi":"10.1016/j.atherosclerosis.2025.120333","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":"407 ","pages":"Article 120333"},"PeriodicalIF":5.7000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nonclinical data demonstrate potent and precise inactivation of liver PCSK9 in vivo with the clinical stage GalNAc base editing medicine, VERVE-102\",\"authors\":\"Ellen Rohde, Richard Lee, Anne Marie Mazzola, Colin Platt, Taiji Mizoguchi, Kim Pendino, Alexandra Chadwick, Amit Khera, Scott Vafai, Sekar Kathiresan, Troy Lister, Joseph Biedenkapp\",\"doi\":\"10.1016/j.atherosclerosis.2025.120333\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":8623,\"journal\":{\"name\":\"Atherosclerosis\",\"volume\":\"407 \",\"pages\":\"Article 120333\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2025-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Atherosclerosis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0021915025012316\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atherosclerosis","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021915025012316","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}