Donguk Lee, James D Lewis, Ashley Harkrider, Mark Hedrick
{"title":"对侧噪声对皮层听觉诱发电位潜伏期和振幅的影响。","authors":"Donguk Lee, James D Lewis, Ashley Harkrider, Mark Hedrick","doi":"10.1044/2025_JSLHR-24-00698","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>There is evidence from past animal work that the neural signal-to-noise ratio (SNR) is modulated through the action of the medial olivocochlear reflex (MOCR). This is commonly referred to as unmasking. However, evidence of unmasking in humans is limited, perhaps due to the traditional approach of measuring the MOCR using otoacoustic emissions-a preneural metric. The amplitudes and latencies of the late latency response (LLR) are sensitive to changes in SNR and may provide a means to noninvasively evaluate MOCR unmasking at the neural level. The purpose of this study was to investigate MOCR-mediated enhancement of ipsilateral noise in humans using the LLR.</p><p><strong>Method: </strong>Fifty normal-hearing adults were recruited. The LLR was measured for a 60 dB SPL, 1-kHz tone in both ipsilateral quiet and ipsilateral noise, with and without presentation of contralateral noise. For the ipsilateral noise conditions, the noise was presented at three different levels to achieve SNRs of +5 dB, +15 dB, and +25 dB. The contralateral noise was always 60 dB SPL white noise. LLR latencies (P1, N1, and P2) and interpeak amplitudes (P1-N1 and N1-P2) were measured for all conditions. In addition, otoacoustic emissions (OAEs) for a 1-kHz tone burst were measured in ipsilateral quiet both with and without contralateral noise. The same contralateral noise was used for both OAEs and LLRs.</p><p><strong>Results: </strong>For the ipsilateral noise conditions, SNR had a significant effect on LLR latencies and interpeak amplitudes: Latencies decreased, and amplitudes increased as SNR improved. The presentation of contralateral noise had a significant effect on P1 and N1 latencies, both of which decreased. LLR interpeak amplitudes significantly increased upon the presentation of contralateral noise. For the ipsilateral quiet condition, there were no significant effects of contralateral noise on LLR metrics. Though OAE magnitudes were significantly reduced upon presentation of contralateral noise, consistent significant relationships between OAE magnitude changes and changes in the LLR metrics were not found.</p><p><strong>Conclusion: </strong>Findings suggest that the presentation of contralateral noise enhances the neural response to an ipsilateral noise, potentially through MOC efferent feedback.</p><p><strong>Supplemental material: </strong>https://doi.org/10.23641/asha.29441903.</p>","PeriodicalId":520690,"journal":{"name":"Journal of speech, language, and hearing research : JSLHR","volume":" ","pages":"1-16"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Contralateral Noise on Cortical Auditory Evoked Potential Latencies and Amplitudes.\",\"authors\":\"Donguk Lee, James D Lewis, Ashley Harkrider, Mark Hedrick\",\"doi\":\"10.1044/2025_JSLHR-24-00698\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>There is evidence from past animal work that the neural signal-to-noise ratio (SNR) is modulated through the action of the medial olivocochlear reflex (MOCR). This is commonly referred to as unmasking. However, evidence of unmasking in humans is limited, perhaps due to the traditional approach of measuring the MOCR using otoacoustic emissions-a preneural metric. The amplitudes and latencies of the late latency response (LLR) are sensitive to changes in SNR and may provide a means to noninvasively evaluate MOCR unmasking at the neural level. The purpose of this study was to investigate MOCR-mediated enhancement of ipsilateral noise in humans using the LLR.</p><p><strong>Method: </strong>Fifty normal-hearing adults were recruited. The LLR was measured for a 60 dB SPL, 1-kHz tone in both ipsilateral quiet and ipsilateral noise, with and without presentation of contralateral noise. For the ipsilateral noise conditions, the noise was presented at three different levels to achieve SNRs of +5 dB, +15 dB, and +25 dB. The contralateral noise was always 60 dB SPL white noise. LLR latencies (P1, N1, and P2) and interpeak amplitudes (P1-N1 and N1-P2) were measured for all conditions. In addition, otoacoustic emissions (OAEs) for a 1-kHz tone burst were measured in ipsilateral quiet both with and without contralateral noise. The same contralateral noise was used for both OAEs and LLRs.</p><p><strong>Results: </strong>For the ipsilateral noise conditions, SNR had a significant effect on LLR latencies and interpeak amplitudes: Latencies decreased, and amplitudes increased as SNR improved. The presentation of contralateral noise had a significant effect on P1 and N1 latencies, both of which decreased. LLR interpeak amplitudes significantly increased upon the presentation of contralateral noise. For the ipsilateral quiet condition, there were no significant effects of contralateral noise on LLR metrics. 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引用次数: 0
摘要
目的：过去的动物实验证明，神经信噪比（SNR）是通过内侧耳蜗反射（MOCR）的作用调节的。这通常被称为揭面具。然而，在人类中发现掩膜的证据有限，这可能是由于使用耳声发射（一种前神经测量方法）测量MOCR的传统方法所致。晚潜伏期反应（LLR）的振幅和潜伏期对信噪比的变化很敏感，可以提供一种在神经水平上无创评估MOCR揭膜的方法。本研究的目的是研究mocr介导的同侧噪声在人类使用LLR时的增强。方法：招募50名听力正常的成年人。测量了60 dB SPL， 1 khz音调在同侧安静和同侧噪声，有和没有对侧噪声的情况下的LLR。对于同侧噪声条件，噪声以三种不同的水平呈现，以实现+5 dB， +15 dB和+25 dB的信噪比。对侧噪声均为60 dB SPL的白噪声。测量所有条件下的LLR潜伏期（P1， N1和P2）和峰间振幅（P1-N1和N1-P2）。此外，在有和没有对侧噪声的同侧安静情况下，测量了1 khz音调爆发的耳声发射（oae）。对于oae和llr使用相同的对侧噪声。结果：在同侧噪声条件下，信噪比对LLR潜伏期和峰间幅值有显著影响：随着信噪比的提高，潜伏期降低，幅值增加。对侧噪声的出现对P1和N1潜伏期有显著影响，两者均降低。当对侧噪声出现时，LLR峰间幅值显著增加。在同侧安静条件下，对侧噪声对LLR指标没有显著影响。虽然在对侧噪声出现时OAE震级显著降低，但没有发现OAE震级变化与LLR指标变化之间存在一致的显著关系。结论：研究结果表明，对侧噪声的出现可能通过MOC传出反馈增强了对同侧噪声的神经反应。补充资料：https://doi.org/10.23641/asha.29441903。
Effects of Contralateral Noise on Cortical Auditory Evoked Potential Latencies and Amplitudes.
Purpose: There is evidence from past animal work that the neural signal-to-noise ratio (SNR) is modulated through the action of the medial olivocochlear reflex (MOCR). This is commonly referred to as unmasking. However, evidence of unmasking in humans is limited, perhaps due to the traditional approach of measuring the MOCR using otoacoustic emissions-a preneural metric. The amplitudes and latencies of the late latency response (LLR) are sensitive to changes in SNR and may provide a means to noninvasively evaluate MOCR unmasking at the neural level. The purpose of this study was to investigate MOCR-mediated enhancement of ipsilateral noise in humans using the LLR.
Method: Fifty normal-hearing adults were recruited. The LLR was measured for a 60 dB SPL, 1-kHz tone in both ipsilateral quiet and ipsilateral noise, with and without presentation of contralateral noise. For the ipsilateral noise conditions, the noise was presented at three different levels to achieve SNRs of +5 dB, +15 dB, and +25 dB. The contralateral noise was always 60 dB SPL white noise. LLR latencies (P1, N1, and P2) and interpeak amplitudes (P1-N1 and N1-P2) were measured for all conditions. In addition, otoacoustic emissions (OAEs) for a 1-kHz tone burst were measured in ipsilateral quiet both with and without contralateral noise. The same contralateral noise was used for both OAEs and LLRs.
Results: For the ipsilateral noise conditions, SNR had a significant effect on LLR latencies and interpeak amplitudes: Latencies decreased, and amplitudes increased as SNR improved. The presentation of contralateral noise had a significant effect on P1 and N1 latencies, both of which decreased. LLR interpeak amplitudes significantly increased upon the presentation of contralateral noise. For the ipsilateral quiet condition, there were no significant effects of contralateral noise on LLR metrics. Though OAE magnitudes were significantly reduced upon presentation of contralateral noise, consistent significant relationships between OAE magnitude changes and changes in the LLR metrics were not found.
Conclusion: Findings suggest that the presentation of contralateral noise enhances the neural response to an ipsilateral noise, potentially through MOC efferent feedback.
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