Carolina Dos Santos Santinoni, Jéssica Pestana, Lívia Apolito Rissi, Milena de Queiroz Guedes, Graziela Garrido Mori Panucci
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Are Extracellular Vesicles Used in Tissue Engineering Effective for Regenerative Endodontic Treatments? Scoping Review.
The purpose was to analyse the efficacy of extracellular vesicles (EVs) used in tissue engineering for regenerative endodontic treatments. The study followed the Guidance's recommendations for conducting systematic scoping reviews. A systematic electronic search was conducted to answer: "Are extracellular vesicles used in tissue engineering effective for regenerative endodontic treatments?". A total of 393 scientific articles were selected, and after applying the inclusion criteria and excluding duplicate articles, 14 articles were included in this research. The most used EVs were exosomes, which were mostly extracted from stem cells and used in association with biomaterials or cells. All included studies demonstrated the effectiveness of extracellular vesicles in promoting pulp regeneration. The mechanisms involved in tissue formation include odontogenic and angiogenic differentiation, as well as control of the inflammatory process after the use of EVs. It is concluded that therapy with EVs is promising for endodontic clinics.
期刊介绍：
The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues.
The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses.
The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.
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