共享宿主,不同的入侵者:疟原虫和巴贝虫在宿主红细胞中的代谢组学足迹。

IF 2.9 3区 医学 Q2 HEMATOLOGY
Divya Beri, Marilis Rodriguez, Cheryl A Lobo
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引用次数: 0

摘要

综述目的:疟疾和巴贝斯虫病是重要的输血传播疾病,因此,报道致病寄生虫与其共同宿主红细胞之间复杂相互作用的新见解非常重要。代谢组学是一种重要的工具,可用于揭示宿主环境下寄生虫感染的深入分析。本文综述了疟疾和巴贝虫感染的红细胞生化指纹图谱的异同,以及这些差异的潜在原因和对宿主的影响。最新发现:巴贝虫感染红细胞的最新结果为开发两种感染的发病机制的比较模型提供了机会。包括糖、氨基酸和脂质在内的关键生物分子水平的扰动,以及氧化还原稳态和血红素利用,是这两种疾病的标志。关键的相似之处包括两种感染红细胞的糖酵解率增强以及红细胞膜的脂质清除。不同之处在于血红蛋白的分解和繁殖所需氨基酸的使用。摘要:代谢谱的改变反映了疟原虫和巴贝斯虫独特的生命周期,指出了它们如何为成功的增殖开辟一个生态位。全面了解这两种寄生虫之间的代谢异同将有助于确定新的生物标志物以及特定的、有效的靶向治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Shared host, distinct invaders: metabolomic footprints of plasmodium and babesia in host red cells.

Purpose of review: Malaria and babesiosis are important transfusion-transmitted diseases, therefore, it is important to report novel insights into the complex interactions the causative parasites share with their common host RBCs. Metabolomics is an important tool that can be used to reveal an in-depth analysis of parasite infections in the context of the host. Similarities and differences in the biochemical fingerprints between malaria and babesia infected RBCs are reviewed with potential reasons for these differences and implications for the host.

Recent findings: Recent results from Babesia-infected RBCs offer an opportunity to develop comparative models of pathogenesis for both infections. Perturbation in the levels of key biomolecules including sugars, amino-acids and lipids, along with redox homeostasis, and heme utilization, are hallmarks of both diseases. Key similarities include enhanced glycolytic rate in both infected RBCs together with lipid scavenging from RBC membranes. Differences relate to hemoglobin breakdown and the use of resultant amino acids for propagation.

Summary: Altered metabolic profiles reflect the unique lifecycles of Plasmodium and Babesia, pointing to how they carve out a niche for successful proliferation. A comprehensive understanding of the metabolic similarities and differences between the two parasites will aid in identifying new biomarkers as well as specific, effective targeted therapies.

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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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