{"title":"共享宿主,不同的入侵者:疟原虫和巴贝虫在宿主红细胞中的代谢组学足迹。","authors":"Divya Beri, Marilis Rodriguez, Cheryl A Lobo","doi":"10.1097/MOH.0000000000000891","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Malaria and babesiosis are important transfusion-transmitted diseases, therefore, it is important to report novel insights into the complex interactions the causative parasites share with their common host RBCs. Metabolomics is an important tool that can be used to reveal an in-depth analysis of parasite infections in the context of the host. Similarities and differences in the biochemical fingerprints between malaria and babesia infected RBCs are reviewed with potential reasons for these differences and implications for the host.</p><p><strong>Recent findings: </strong>Recent results from Babesia-infected RBCs offer an opportunity to develop comparative models of pathogenesis for both infections. Perturbation in the levels of key biomolecules including sugars, amino-acids and lipids, along with redox homeostasis, and heme utilization, are hallmarks of both diseases. Key similarities include enhanced glycolytic rate in both infected RBCs together with lipid scavenging from RBC membranes. Differences relate to hemoglobin breakdown and the use of resultant amino acids for propagation.</p><p><strong>Summary: </strong>Altered metabolic profiles reflect the unique lifecycles of Plasmodium and Babesia, pointing to how they carve out a niche for successful proliferation. A comprehensive understanding of the metabolic similarities and differences between the two parasites will aid in identifying new biomarkers as well as specific, effective targeted therapies.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425148/pdf/","citationCount":"0","resultStr":"{\"title\":\"Shared host, distinct invaders: metabolomic footprints of plasmodium and babesia in host red cells.\",\"authors\":\"Divya Beri, Marilis Rodriguez, Cheryl A Lobo\",\"doi\":\"10.1097/MOH.0000000000000891\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>Malaria and babesiosis are important transfusion-transmitted diseases, therefore, it is important to report novel insights into the complex interactions the causative parasites share with their common host RBCs. Metabolomics is an important tool that can be used to reveal an in-depth analysis of parasite infections in the context of the host. Similarities and differences in the biochemical fingerprints between malaria and babesia infected RBCs are reviewed with potential reasons for these differences and implications for the host.</p><p><strong>Recent findings: </strong>Recent results from Babesia-infected RBCs offer an opportunity to develop comparative models of pathogenesis for both infections. Perturbation in the levels of key biomolecules including sugars, amino-acids and lipids, along with redox homeostasis, and heme utilization, are hallmarks of both diseases. Key similarities include enhanced glycolytic rate in both infected RBCs together with lipid scavenging from RBC membranes. Differences relate to hemoglobin breakdown and the use of resultant amino acids for propagation.</p><p><strong>Summary: </strong>Altered metabolic profiles reflect the unique lifecycles of Plasmodium and Babesia, pointing to how they carve out a niche for successful proliferation. A comprehensive understanding of the metabolic similarities and differences between the two parasites will aid in identifying new biomarkers as well as specific, effective targeted therapies.</p>\",\"PeriodicalId\":55196,\"journal\":{\"name\":\"Current Opinion in Hematology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425148/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MOH.0000000000000891\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MOH.0000000000000891","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Shared host, distinct invaders: metabolomic footprints of plasmodium and babesia in host red cells.
Purpose of review: Malaria and babesiosis are important transfusion-transmitted diseases, therefore, it is important to report novel insights into the complex interactions the causative parasites share with their common host RBCs. Metabolomics is an important tool that can be used to reveal an in-depth analysis of parasite infections in the context of the host. Similarities and differences in the biochemical fingerprints between malaria and babesia infected RBCs are reviewed with potential reasons for these differences and implications for the host.
Recent findings: Recent results from Babesia-infected RBCs offer an opportunity to develop comparative models of pathogenesis for both infections. Perturbation in the levels of key biomolecules including sugars, amino-acids and lipids, along with redox homeostasis, and heme utilization, are hallmarks of both diseases. Key similarities include enhanced glycolytic rate in both infected RBCs together with lipid scavenging from RBC membranes. Differences relate to hemoglobin breakdown and the use of resultant amino acids for propagation.
Summary: Altered metabolic profiles reflect the unique lifecycles of Plasmodium and Babesia, pointing to how they carve out a niche for successful proliferation. A comprehensive understanding of the metabolic similarities and differences between the two parasites will aid in identifying new biomarkers as well as specific, effective targeted therapies.
期刊介绍:
Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.