Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto
{"title":"肺癌术后纵隔淋巴结间皮细胞包涵1例。","authors":"Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto","doi":"10.1002/rcr2.70276","DOIUrl":null,"url":null,"abstract":"<p><p>Mesothelial-cell inclusion (MCI) is an inclusion of mesothelial cells found in lymph nodes. Although it is a rare condition, differentiating it from lymph node metastasis is essential to avoid a misdiagnosis. We reported, for the first time, a case of MCI after lung cancer surgery. The patient was a 76-year-old Japanese man with a history of bilateral radical surgery for lung cancer. Follow-up computed tomography performed at 7 years after the initial surgery revealed an enlarged right cardiophrenic angle lymph node. It was resected through video-assisted thoracic surgery, and histopathology revealed non-dysplastic ductal proliferation. Immunohistochemistry was positive for AE1/3, D2-40, calretinin, and WT-1, and negative for CD31, CD34, and factor VIII. Based on these findings, MCI was finally diagnosed. Although the presence of metastasis is the first possible cause for the enlarged lymph nodes in such cases, MCI must also be considered.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 7","pages":"e70276"},"PeriodicalIF":0.8000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266986/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Case of Mesothelial-Cell Inclusions in the Mediastinal Lymph Nodes After Lung Cancer Surgery.\",\"authors\":\"Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto\",\"doi\":\"10.1002/rcr2.70276\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mesothelial-cell inclusion (MCI) is an inclusion of mesothelial cells found in lymph nodes. Although it is a rare condition, differentiating it from lymph node metastasis is essential to avoid a misdiagnosis. We reported, for the first time, a case of MCI after lung cancer surgery. The patient was a 76-year-old Japanese man with a history of bilateral radical surgery for lung cancer. Follow-up computed tomography performed at 7 years after the initial surgery revealed an enlarged right cardiophrenic angle lymph node. It was resected through video-assisted thoracic surgery, and histopathology revealed non-dysplastic ductal proliferation. Immunohistochemistry was positive for AE1/3, D2-40, calretinin, and WT-1, and negative for CD31, CD34, and factor VIII. Based on these findings, MCI was finally diagnosed. Although the presence of metastasis is the first possible cause for the enlarged lymph nodes in such cases, MCI must also be considered.</p>\",\"PeriodicalId\":45846,\"journal\":{\"name\":\"Respirology Case Reports\",\"volume\":\"13 7\",\"pages\":\"e70276\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266986/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respirology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/rcr2.70276\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rcr2.70276","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
A Case of Mesothelial-Cell Inclusions in the Mediastinal Lymph Nodes After Lung Cancer Surgery.
Mesothelial-cell inclusion (MCI) is an inclusion of mesothelial cells found in lymph nodes. Although it is a rare condition, differentiating it from lymph node metastasis is essential to avoid a misdiagnosis. We reported, for the first time, a case of MCI after lung cancer surgery. The patient was a 76-year-old Japanese man with a history of bilateral radical surgery for lung cancer. Follow-up computed tomography performed at 7 years after the initial surgery revealed an enlarged right cardiophrenic angle lymph node. It was resected through video-assisted thoracic surgery, and histopathology revealed non-dysplastic ductal proliferation. Immunohistochemistry was positive for AE1/3, D2-40, calretinin, and WT-1, and negative for CD31, CD34, and factor VIII. Based on these findings, MCI was finally diagnosed. Although the presence of metastasis is the first possible cause for the enlarged lymph nodes in such cases, MCI must also be considered.
期刊介绍：
Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
