{"title":"COVID-19疫苗诱导的系统性红斑狼疮：潜在的免疫学和遗传学机制。","authors":"Ping Wang, Shanzhao Jin, Xue Li, Huaqun Zhu, Fanlei Hu, Zhanguo Li","doi":"10.1177/09612033251357627","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveSystemic lupus erythematosus (SLE) is complexed with multi systemic involvements associated with genetic and environmental factors. Herein, we delve into the molecular mechanism behind COVID-19 vaccine-induced SLE.MethodsTo elucidating the molecular mechanism, we employed the whole genome sequencing (WGS) and immune cell RNA sequencing of CD4<sup>+</sup> T, CD8<sup>+</sup> T, and B cells.ResultsOur findings suggest that in genetically predisposed individuals, COVID-19 vaccination might provoke SLE by triggering host-harbored virus signaling and cytokine pathway-associated immune response.ConclusionsThis study deepens the underlying mechanism and highlights the importance of evaluating the genetic susceptibility to autoimmune disease before COVID-19 vaccination.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1061-1066"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"COVID-19 vaccine-induced systemic lupus erythematosus: The underlying immunological and genetic mechanisms.\",\"authors\":\"Ping Wang, Shanzhao Jin, Xue Li, Huaqun Zhu, Fanlei Hu, Zhanguo Li\",\"doi\":\"10.1177/09612033251357627\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveSystemic lupus erythematosus (SLE) is complexed with multi systemic involvements associated with genetic and environmental factors. Herein, we delve into the molecular mechanism behind COVID-19 vaccine-induced SLE.MethodsTo elucidating the molecular mechanism, we employed the whole genome sequencing (WGS) and immune cell RNA sequencing of CD4<sup>+</sup> T, CD8<sup>+</sup> T, and B cells.ResultsOur findings suggest that in genetically predisposed individuals, COVID-19 vaccination might provoke SLE by triggering host-harbored virus signaling and cytokine pathway-associated immune response.ConclusionsThis study deepens the underlying mechanism and highlights the importance of evaluating the genetic susceptibility to autoimmune disease before COVID-19 vaccination.</p>\",\"PeriodicalId\":18044,\"journal\":{\"name\":\"Lupus\",\"volume\":\" \",\"pages\":\"1061-1066\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lupus\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09612033251357627\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033251357627","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
COVID-19 vaccine-induced systemic lupus erythematosus: The underlying immunological and genetic mechanisms.
ObjectiveSystemic lupus erythematosus (SLE) is complexed with multi systemic involvements associated with genetic and environmental factors. Herein, we delve into the molecular mechanism behind COVID-19 vaccine-induced SLE.MethodsTo elucidating the molecular mechanism, we employed the whole genome sequencing (WGS) and immune cell RNA sequencing of CD4+ T, CD8+ T, and B cells.ResultsOur findings suggest that in genetically predisposed individuals, COVID-19 vaccination might provoke SLE by triggering host-harbored virus signaling and cytokine pathway-associated immune response.ConclusionsThis study deepens the underlying mechanism and highlights the importance of evaluating the genetic susceptibility to autoimmune disease before COVID-19 vaccination.
期刊介绍：
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
