乳腺多能性的重新激活-池塘中的涟漪和潮汐的转变。

IF 3.6 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM
C Hager, C Jehanno, M Bentires-Alj
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引用次数: 0

摘要

多能性指的是细胞分化为多种的能力,但与多能性相反,多能性指的是特定谱系或组织内细胞类型的数量。使用乳腺转基因小鼠模型的研究揭示了一种细胞层次结构,其中管状和基底谱系都由单能祖细胞补充。因此,尽管存在双能性干细胞,正常的乳腺稳态与单能性密切相关。然而,最近的文献显示,在特定的生理或实验条件下,谱系限制的乳腺细胞可以重新获得多能性并进行谱系转换,挑战了传统的单向细胞分化模型。这种多能性的再激活已经被观察到,例如,在对怀孕、谱系消融或致癌刺激的反应中,表明一定程度的可塑性可能在肿瘤发生的背景下产生后果。了解控制这一现象的分子机制可以为了解乳腺细胞等级和乳腺癌进展提供有价值的见解。事实上,多能性的再激活是细胞可塑性发展的结果,它可以驱动肿瘤的异质性,促进疾病的侵袭性并阻碍诊断。本文综述了推断多能性再激活的模型,讨论了潜在的分子和细胞机制,并提出了未来的研究前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reactivation of Multipotency in the Mammary Gland - a Ripple in the Pond and a Turn of the Tide.

Reactivation of Multipotency in the Mammary Gland - a Ripple in the Pond and a Turn of the Tide.

Multipotency refers to the ability of a cell to differentiate into multiple, yet limited as opposed to pluripotency, number of cell types within a specific lineage or tissue. Studies using transgenic mouse models of the mammary gland have revealed a cellular hierarchy in which both luminal and basal lineages are replenished by unipotent progenitor cells. Hence, despite the existence of bipotent stem cells, normal mammary gland homeostasis is intimately linked with unipotency. However, recent literature revealed that under specific physiological or experimental conditions, lineage-restricted mammary cells can reacquire multipotency and undergo a lineage switch, challenging the traditional unidirectional model of cell differentiation. This reactivation of multipotency has been observed, for instance, in response to pregnancy, lineage ablation or oncogenic stimuli, indicating a certain level of plasticity that may have consequences in the context of tumorigenesis. Understanding the molecular mechanisms governing this phenomenon could provide valuable insights into mammary gland cellular hierarchy and breast cancer progression. Indeed, reactivation of multipotency is a result of developed cell plasticity, which can drive tumor heterogeneity, promote disease aggressiveness and hamper diagnosis. This review provides an overview of models that have inferred reactivation of multipotency, discusses the underlying molecular and cellular mechanisms and proposes future perspectives for research.

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来源期刊
Journal of Mammary Gland Biology and Neoplasia
Journal of Mammary Gland Biology and Neoplasia 医学-内分泌学与代谢
CiteScore
5.30
自引率
4.00%
发文量
22
期刊介绍: Journal of Mammary Gland Biology and Neoplasia is the leading Journal in the field of mammary gland biology that provides researchers within and outside the field of mammary gland biology with an integrated source of information pertaining to the development, function, and pathology of the mammary gland and its function. Commencing in 2015, the Journal will begin receiving and publishing a combination of reviews and original, peer-reviewed research. The Journal covers all topics related to the field of mammary gland biology, including mammary development, breast cancer biology, lactation, and milk composition and quality. The environmental, endocrine, nutritional, and molecular factors regulating these processes is covered, including from a comparative biology perspective.
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