强迫症和抑郁症中奖励加工的跨诊断联系。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-07-16 DOI:10.1016/j.jad.2025.119886

Kevin M. Wagner , Matti Cervin , Jessica S.C. Cheng , Jasmine Arriaga , Vanessa Zavala Cruz , Dayan Berrones , Josselyn S. Muñoz , Renee M. Frederick , Jacey L. Anderberg , Belinda E. Núñez Bracho , Victor R. Adorno , Leonardo F. Fontenelle , Andrew D. Wiese

{"title":"强迫症和抑郁症中奖励加工的跨诊断联系。","authors":"Kevin M. Wagner , Matti Cervin , Jessica S.C. Cheng , Jasmine Arriaga , Vanessa Zavala Cruz , Dayan Berrones , Josselyn S. Muñoz , Renee M. Frederick , Jacey L. Anderberg , Belinda E. Núñez Bracho , Victor R. Adorno , Leonardo F. Fontenelle , Andrew D. Wiese","doi":"10.1016/j.jad.2025.119886","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.</div></div><div><h3>Methods</h3><div>A total of 1345 individuals with a history of OCD symptoms (ages 18–88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated measures of reward responsiveness, OCD, and depression. Network analyses evaluated interrelations among reward responsiveness domains and their links to OCD and depression.</div></div><div><h3>Results</h3><div>Hobbies and social interactions were the most central domains in the reward responsiveness network. Higher OCD severity was uniquely associated with lower responsiveness to social interactions, while higher depression severity was uniquely linked to reduced responsiveness in hobbies and goal-directed behaviors.</div></div><div><h3>Conclusions</h3><div>Reward responsiveness is relevant to both OCD and depression. Interventions that enhance engagement in central domains, such as hobbies and social interactions, may improve outcomes. Future research should explore reward responsiveness in other mental disorders to inform transdiagnostic intervention strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"391 ","pages":"Article 119886"},"PeriodicalIF":4.9000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression\",\"authors\":\"Kevin M. Wagner , Matti Cervin , Jessica S.C. Cheng , Jasmine Arriaga , Vanessa Zavala Cruz , Dayan Berrones , Josselyn S. Muñoz , Renee M. Frederick , Jacey L. Anderberg , Belinda E. Núñez Bracho , Victor R. Adorno , Leonardo F. Fontenelle , Andrew D. Wiese\",\"doi\":\"10.1016/j.jad.2025.119886\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.</div></div><div><h3>Methods</h3><div>A total of 1345 individuals with a history of OCD symptoms (ages 18–88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated measures of reward responsiveness, OCD, and depression. Network analyses evaluated interrelations among reward responsiveness domains and their links to OCD and depression.</div></div><div><h3>Results</h3><div>Hobbies and social interactions were the most central domains in the reward responsiveness network. Higher OCD severity was uniquely associated with lower responsiveness to social interactions, while higher depression severity was uniquely linked to reduced responsiveness in hobbies and goal-directed behaviors.</div></div><div><h3>Conclusions</h3><div>Reward responsiveness is relevant to both OCD and depression. Interventions that enhance engagement in central domains, such as hobbies and social interactions, may improve outcomes. Future research should explore reward responsiveness in other mental disorders to inform transdiagnostic intervention strategies.</div></div>\",\"PeriodicalId\":14963,\"journal\":{\"name\":\"Journal of affective disorders\",\"volume\":\"391 \",\"pages\":\"Article 119886\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of affective disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S016503272501328X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016503272501328X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：跨诊断模型旨在揭示精神障碍的共同机制。奖励反应（从奖励刺激中体验快乐的能力）是一种似是而非的跨诊断机制，将强迫症（OCD）和抑郁症联系起来。本研究使用网络分析来(1)检查强迫症患者的关键奖励反应域是如何相互联系的；(2)探索每个域如何与强迫症和抑郁症独特地联系在一起。方法：来自美国（包括波多黎各）和9个拉丁美洲国家的拉丁裔社区共有1345名有强迫症症状史的个体（年龄18-88岁，71% 为女性）完成了奖励反应、强迫症和抑郁症的验证测量。网络分析评估了奖励反应域之间的相互关系及其与强迫症和抑郁症的联系。结果：兴趣爱好和社会交往是奖励反应网络的核心领域。较高的强迫症严重程度与较低的社会互动反应有关，而较高的抑郁严重程度与爱好和目标导向行为的反应性降低有关。结论：奖励反应与强迫症和抑郁症均相关。增强核心领域（如爱好和社会互动）参与度的干预措施可能会改善结果。未来的研究应该探索其他精神障碍的奖励反应，为跨诊断干预策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression

Objectives

Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.

Methods

A total of 1345 individuals with a history of OCD symptoms (ages 18–88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated measures of reward responsiveness, OCD, and depression. Network analyses evaluated interrelations among reward responsiveness domains and their links to OCD and depression.

Results

Hobbies and social interactions were the most central domains in the reward responsiveness network. Higher OCD severity was uniquely associated with lower responsiveness to social interactions, while higher depression severity was uniquely linked to reduced responsiveness in hobbies and goal-directed behaviors.

Conclusions

Reward responsiveness is relevant to both OCD and depression. Interventions that enhance engagement in central domains, such as hobbies and social interactions, may improve outcomes. Future research should explore reward responsiveness in other mental disorders to inform transdiagnostic intervention strategies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.