{"title":"单中心粪便钙保护蛋白在早产儿坏死性小肠结肠炎早期诊断和评估中的价值。","authors":"Chen ZongLi, Luo KeYong, Jiang Liang","doi":"10.3389/fped.2025.1598448","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the value of fecal calprotectin (FC) in the early diagnosis of necrotizing enterocolitis (NEC) in premature infants.</p><p><strong>Methods: </strong>From September 2021 to June 2024, 84 premature infants with NEC were selected as the NEC group, and 84 premature infants with feeding intolerance (feeding intolerance group) and 168 healthy premature infants (healthy group) were selected at the same time. ROC curves were used to analyze the value of FC in the early diagnosis and condition evaluation of NEC in premature infants, and Spearman correlations were used to analyze the relationships between FC and the occurrence and severity of NEC in premature infants.</p><p><strong>Results: </strong>FC levels in the NEC group were greater than those in the feeding intolerance group and healthy group (<i>P</i> < 0.05), and there was no significant difference between the feeding intolerance group and the healthy group (<i>P</i> > 0.05). The FC level of premature infants with NEC III was greater than that of premature infants with NEC Ⅰ and Ⅱ, and the FC level of premature infants with NEC II was greater than that of premature infants with NEC Ⅰ (<i>P</i> < 0.05). ROC curve analysis revealed that the best diagnostic values of FC for premature infants with NEC and their conditions were 8.40 μg/g and 53.50 μg/g, respectively, and the AUCs were 0.651 and 0.901, respectively, with sensitivities of 42.86% and 85.71%, specificities of 89.23% and 82.61%, respectively. Spearman correlation analysis revealed that FC was positively correlated with the occurrence and severity of NEC in premature infants (<i>r</i> <sub>s</sub> = 0.401, 0.853; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The level of FC in premature infants with NEC is abnormally high, and FC has high clinical value for early diagnosis and condition evaluation of premature infants with NEC, which is worthy of further investigation.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1598448"},"PeriodicalIF":2.1000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267261/pdf/","citationCount":"0","resultStr":"{\"title\":\"Value of single-center fecal calprotectin in the early diagnosis and assessment of necrotizing enterocolitis in premature infants.\",\"authors\":\"Chen ZongLi, Luo KeYong, Jiang Liang\",\"doi\":\"10.3389/fped.2025.1598448\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the value of fecal calprotectin (FC) in the early diagnosis of necrotizing enterocolitis (NEC) in premature infants.</p><p><strong>Methods: </strong>From September 2021 to June 2024, 84 premature infants with NEC were selected as the NEC group, and 84 premature infants with feeding intolerance (feeding intolerance group) and 168 healthy premature infants (healthy group) were selected at the same time. ROC curves were used to analyze the value of FC in the early diagnosis and condition evaluation of NEC in premature infants, and Spearman correlations were used to analyze the relationships between FC and the occurrence and severity of NEC in premature infants.</p><p><strong>Results: </strong>FC levels in the NEC group were greater than those in the feeding intolerance group and healthy group (<i>P</i> < 0.05), and there was no significant difference between the feeding intolerance group and the healthy group (<i>P</i> > 0.05). The FC level of premature infants with NEC III was greater than that of premature infants with NEC Ⅰ and Ⅱ, and the FC level of premature infants with NEC II was greater than that of premature infants with NEC Ⅰ (<i>P</i> < 0.05). ROC curve analysis revealed that the best diagnostic values of FC for premature infants with NEC and their conditions were 8.40 μg/g and 53.50 μg/g, respectively, and the AUCs were 0.651 and 0.901, respectively, with sensitivities of 42.86% and 85.71%, specificities of 89.23% and 82.61%, respectively. Spearman correlation analysis revealed that FC was positively correlated with the occurrence and severity of NEC in premature infants (<i>r</i> <sub>s</sub> = 0.401, 0.853; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The level of FC in premature infants with NEC is abnormally high, and FC has high clinical value for early diagnosis and condition evaluation of premature infants with NEC, which is worthy of further investigation.</p>\",\"PeriodicalId\":12637,\"journal\":{\"name\":\"Frontiers in Pediatrics\",\"volume\":\"13 \",\"pages\":\"1598448\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267261/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fped.2025.1598448\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fped.2025.1598448","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨粪钙保护蛋白（FC）在早产儿坏死性小肠结肠炎（NEC）早期诊断中的价值。方法：选取2021年9月~ 2024年6月84例NEC早产儿作为NEC组，同时选取84例喂养不耐受早产儿（喂养不耐受组）和168例健康早产儿（健康组）。采用ROC曲线分析FC在早产儿NEC早期诊断及病情评价中的价值，采用Spearman相关分析FC与早产儿NEC发生及严重程度的关系。结果：NEC组FC水平高于喂养不耐受组和健康组（P < 0.05）。NEC III型早产儿FC水平高于NECⅠ和Ⅱ型早产儿，NEC II型早产儿FC水平高于NECⅠ型早产儿(P r = 0.401, 0.853；P结论：NEC早产儿FC水平异常高，FC对NEC早产儿早期诊断及病情评价具有较高的临床价值，值得进一步探讨。
Value of single-center fecal calprotectin in the early diagnosis and assessment of necrotizing enterocolitis in premature infants.
Objective: To explore the value of fecal calprotectin (FC) in the early diagnosis of necrotizing enterocolitis (NEC) in premature infants.
Methods: From September 2021 to June 2024, 84 premature infants with NEC were selected as the NEC group, and 84 premature infants with feeding intolerance (feeding intolerance group) and 168 healthy premature infants (healthy group) were selected at the same time. ROC curves were used to analyze the value of FC in the early diagnosis and condition evaluation of NEC in premature infants, and Spearman correlations were used to analyze the relationships between FC and the occurrence and severity of NEC in premature infants.
Results: FC levels in the NEC group were greater than those in the feeding intolerance group and healthy group (P < 0.05), and there was no significant difference between the feeding intolerance group and the healthy group (P > 0.05). The FC level of premature infants with NEC III was greater than that of premature infants with NEC Ⅰ and Ⅱ, and the FC level of premature infants with NEC II was greater than that of premature infants with NEC Ⅰ (P < 0.05). ROC curve analysis revealed that the best diagnostic values of FC for premature infants with NEC and their conditions were 8.40 μg/g and 53.50 μg/g, respectively, and the AUCs were 0.651 and 0.901, respectively, with sensitivities of 42.86% and 85.71%, specificities of 89.23% and 82.61%, respectively. Spearman correlation analysis revealed that FC was positively correlated with the occurrence and severity of NEC in premature infants (rs = 0.401, 0.853; P < 0.05).
Conclusion: The level of FC in premature infants with NEC is abnormally high, and FC has high clinical value for early diagnosis and condition evaluation of premature infants with NEC, which is worthy of further investigation.
期刊介绍：
Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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