{"title":"注意缺陷多动障碍静息状态脑网络的结构平衡。","authors":"Ruzbeh Fakhari, Alireza Moradi, Reza Ebrahimpour, Reza Khosrowabadi","doi":"10.32598/bcn.2024.276.3","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The study of brain functional networks in attention deficit hyperactivity disorder (ADHD) has provided useful information about the hyper- or hypo-connectivity between distinct brain regions. Nevertheless, the impact of negative links (antisynchrony) and their topology on the stability of the network still must be investigated.</p><p><strong>Methods: </strong>In this study, we hypothesized that the effect of dysconnectivity and antisynchrony should mainly be local and may not influence the overall stability and flexibility of the network in ADHD. Therefore, differences in brain functional organization of ADHD individuals were compared to a typically developed group using the structural balance theory.</p><p><strong>Results: </strong>Our results did not show any significant differences in the balance-energy of the resting-state network between healthy individuals and three subtypes of ADHD. However, a negative correlation was found between behavioral measures of ADHD and balance energy, highlighting that the higher disorder index may push the network to a less flexible (more balanced) state.</p><p><strong>Conclusion: </strong>We hope these findings enhance our understanding of the systemic mechanism behind ADHD.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"299-308"},"PeriodicalIF":1.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265431/pdf/","citationCount":"0","resultStr":"{\"title\":\"Structural Balance of Resting-state Brain Network in Attention Deficit Hyperactivity Disorder.\",\"authors\":\"Ruzbeh Fakhari, Alireza Moradi, Reza Ebrahimpour, Reza Khosrowabadi\",\"doi\":\"10.32598/bcn.2024.276.3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The study of brain functional networks in attention deficit hyperactivity disorder (ADHD) has provided useful information about the hyper- or hypo-connectivity between distinct brain regions. Nevertheless, the impact of negative links (antisynchrony) and their topology on the stability of the network still must be investigated.</p><p><strong>Methods: </strong>In this study, we hypothesized that the effect of dysconnectivity and antisynchrony should mainly be local and may not influence the overall stability and flexibility of the network in ADHD. Therefore, differences in brain functional organization of ADHD individuals were compared to a typically developed group using the structural balance theory.</p><p><strong>Results: </strong>Our results did not show any significant differences in the balance-energy of the resting-state network between healthy individuals and three subtypes of ADHD. However, a negative correlation was found between behavioral measures of ADHD and balance energy, highlighting that the higher disorder index may push the network to a less flexible (more balanced) state.</p><p><strong>Conclusion: </strong>We hope these findings enhance our understanding of the systemic mechanism behind ADHD.</p>\",\"PeriodicalId\":8701,\"journal\":{\"name\":\"Basic and Clinical Neuroscience\",\"volume\":\"16 Spec\",\"pages\":\"299-308\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265431/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Basic and Clinical Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32598/bcn.2024.276.3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic and Clinical Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/bcn.2024.276.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/18 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Structural Balance of Resting-state Brain Network in Attention Deficit Hyperactivity Disorder.
Introduction: The study of brain functional networks in attention deficit hyperactivity disorder (ADHD) has provided useful information about the hyper- or hypo-connectivity between distinct brain regions. Nevertheless, the impact of negative links (antisynchrony) and their topology on the stability of the network still must be investigated.
Methods: In this study, we hypothesized that the effect of dysconnectivity and antisynchrony should mainly be local and may not influence the overall stability and flexibility of the network in ADHD. Therefore, differences in brain functional organization of ADHD individuals were compared to a typically developed group using the structural balance theory.
Results: Our results did not show any significant differences in the balance-energy of the resting-state network between healthy individuals and three subtypes of ADHD. However, a negative correlation was found between behavioral measures of ADHD and balance energy, highlighting that the higher disorder index may push the network to a less flexible (more balanced) state.
Conclusion: We hope these findings enhance our understanding of the systemic mechanism behind ADHD.
期刊介绍：
BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.
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