The role of type I collagen in white matter injury.

White matter injury is a cerebral pathology marked by the loss of oligodendrocytes and the resultant demyelination. Various mechanisms induce white matter injury, including ischemic stroke and multiple sclerosis. Oligodendrocytes regenerate white matter in the central nervous system in a process called remyelination, ensheathing demyelinated axons with new myelin. While failures of remyelination can be observed in progressive multiple sclerosis and after ischemic stroke, the mechanisms of impaired white matter regeneration remain unclear. In this review, we primarily focus on our recent work while summarizing studies reporting on mouse models of internal capsule demyelination and discuss inhibitory factors affecting white matter regeneration. In addition, we provide recent findings on the role of type I collagen as an inhibitory molecule of remyelination in white matter lesions.