Kang Zi Khor, Adam Azlan, Julia Joseph, Jeyrubini Ramesh, Maheswaran Solayappan, Yee Yik Mot, Mohamed Saleem, Narazah Mohd Yusoff, Emmanuel Jairaj Moses
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The miRNA Landscape of Leukemia - Cellular Actions to Therapy through Molecular Mechanisms.
The Nobel Prize in Physiology and Medicine awarded to Victor Ambros and Gary Ruvkun for their work in microRNA (miRNA) emphasized the important role that miRNA plays in biology. These conserved small noncoding RNA molecules play pivotal role especially in the post transcriptional stage of gene regulation, affecting various key cellular processes by interacting with target genes complement to the conserved miRNA seed sequence. Over the years miRNA was implicated in all manners of diseases with abnormal gene regulation especially in cancer. In leukemia, miRNA dysregulation could lead to aberrant cellular processes. These include but are not limited to leukemic development, survival and drug resistance. miRNA also have important clinical implications as differential miRNA abundance could contribute towards leukemogenesis. This is especially useful in the diagnosis and prognosis of leukemia. This review aims to explore and highlight the role of miRNAs in leukemia development, progression and to discuss miRNA involvement towards leukemic resistance to therapy.
期刊介绍：
Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems
The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.
Examples of subject areas that CBB publishes are:
· biochemical and biophysical aspects of cell structure and function;
· interactions of cells and their molecular/macromolecular constituents;
· innovative developments in genetic and biomolecular engineering;
· computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies;
· photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design
For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.
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