Wantai Dang, Xinru Zheng, Luis E. Muñoz, Marco Muñoz-Becerra, Dan Xu, Martin Herrmann
{"title":"MRI T1和T2灰度值和Sieper/Rudwaleit评分与强直性脊柱炎疾病活动和进展的关系","authors":"Wantai Dang, Xinru Zheng, Luis E. Muñoz, Marco Muñoz-Becerra, Dan Xu, Martin Herrmann","doi":"10.1111/1756-185x.70373","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aimed to investigate the relationship between MRI T1 and T2 grayscale values and Sieper/Rudwaleit score with disease activity and inflammation levels in patients with ankylosing spondylitis (AS).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Totally, 174 AS patients and 41 healthy controls were enrolled and received MRI and computed tomography (CT) of sacroiliac joints (SIJ).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Sieper/Rudwaleit score positively related to CT grade (<i>p</i> = 0.038). MRI T1 values correlated negatively and positively to MRI T2 values (<i>p</i> = 0.001) and CT grade (<i>p</i> = 0.016), respectively. According to multiple linear regression analysis, Sieper/Rudwaleit score showed an independent positive correlation with bone marrow fat deposition and Bath ankylosing spondylitis disease activity index (BASDAI) (both <i>p</i> < 0.001). MRI T1 values exhibited an independent positive correlation with male sex, duration of AS, and BASDAI; while they inversely related to C-reactive protein (CRP), platelets, albumin, and creatinine (all <i>p</i> < 0.05). MRI T2 values exhibited an independent positive correlation with CRP and neutrophils, and a negative correlation to age, male sex, and creatinine (all <i>p</i> < 0.05). CT grade disclosed an independent positive relationship with human leukocyte antigen B27 positivity, duration of AS, ankylosing spondylitis disease activity score, CRP, platelets, and alkaline phosphatase (all <i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>MRI T1 and T2 values combined with the Sieper/Rudwaleit score may serve as potential biomarkers for evaluating inflammatory activity and disease progression in AS. CT serves as an adjunct to MRI to monitor the activity of AS.</p>\n </section>\n </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 7","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of MRI T1 and T2 Grayscale Values and Sieper/Rudwaleit Score With Disease Activity and Progression in Ankylosing Spondylitis\",\"authors\":\"Wantai Dang, Xinru Zheng, Luis E. Muñoz, Marco Muñoz-Becerra, Dan Xu, Martin Herrmann\",\"doi\":\"10.1111/1756-185x.70373\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study aimed to investigate the relationship between MRI T1 and T2 grayscale values and Sieper/Rudwaleit score with disease activity and inflammation levels in patients with ankylosing spondylitis (AS).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Totally, 174 AS patients and 41 healthy controls were enrolled and received MRI and computed tomography (CT) of sacroiliac joints (SIJ).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Sieper/Rudwaleit score positively related to CT grade (<i>p</i> = 0.038). MRI T1 values correlated negatively and positively to MRI T2 values (<i>p</i> = 0.001) and CT grade (<i>p</i> = 0.016), respectively. According to multiple linear regression analysis, Sieper/Rudwaleit score showed an independent positive correlation with bone marrow fat deposition and Bath ankylosing spondylitis disease activity index (BASDAI) (both <i>p</i> < 0.001). MRI T1 values exhibited an independent positive correlation with male sex, duration of AS, and BASDAI; while they inversely related to C-reactive protein (CRP), platelets, albumin, and creatinine (all <i>p</i> < 0.05). MRI T2 values exhibited an independent positive correlation with CRP and neutrophils, and a negative correlation to age, male sex, and creatinine (all <i>p</i> < 0.05). CT grade disclosed an independent positive relationship with human leukocyte antigen B27 positivity, duration of AS, ankylosing spondylitis disease activity score, CRP, platelets, and alkaline phosphatase (all <i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>MRI T1 and T2 values combined with the Sieper/Rudwaleit score may serve as potential biomarkers for evaluating inflammatory activity and disease progression in AS. CT serves as an adjunct to MRI to monitor the activity of AS.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14330,\"journal\":{\"name\":\"International Journal of Rheumatic Diseases\",\"volume\":\"28 7\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Rheumatic Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/1756-185x.70373\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Rheumatic Diseases","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1756-185x.70373","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Association of MRI T1 and T2 Grayscale Values and Sieper/Rudwaleit Score With Disease Activity and Progression in Ankylosing Spondylitis
Objective
This study aimed to investigate the relationship between MRI T1 and T2 grayscale values and Sieper/Rudwaleit score with disease activity and inflammation levels in patients with ankylosing spondylitis (AS).
Methods
Totally, 174 AS patients and 41 healthy controls were enrolled and received MRI and computed tomography (CT) of sacroiliac joints (SIJ).
Results
Sieper/Rudwaleit score positively related to CT grade (p = 0.038). MRI T1 values correlated negatively and positively to MRI T2 values (p = 0.001) and CT grade (p = 0.016), respectively. According to multiple linear regression analysis, Sieper/Rudwaleit score showed an independent positive correlation with bone marrow fat deposition and Bath ankylosing spondylitis disease activity index (BASDAI) (both p < 0.001). MRI T1 values exhibited an independent positive correlation with male sex, duration of AS, and BASDAI; while they inversely related to C-reactive protein (CRP), platelets, albumin, and creatinine (all p < 0.05). MRI T2 values exhibited an independent positive correlation with CRP and neutrophils, and a negative correlation to age, male sex, and creatinine (all p < 0.05). CT grade disclosed an independent positive relationship with human leukocyte antigen B27 positivity, duration of AS, ankylosing spondylitis disease activity score, CRP, platelets, and alkaline phosphatase (all p < 0.05).
Conclusion
MRI T1 and T2 values combined with the Sieper/Rudwaleit score may serve as potential biomarkers for evaluating inflammatory activity and disease progression in AS. CT serves as an adjunct to MRI to monitor the activity of AS.
期刊介绍：
The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
