{"title":"风湿病妇女辅助生殖技术的结果：一项回顾性队列研究","authors":"Elham Manouchehri, Fatemeh Jalalmarvi, Vahid Ghavami, Zahra Mirfeizi, Nayereh Khadem, Maryam Sahebari","doi":"10.1111/1756-185x.70374","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The multisystem nature of rheumatic diseases (RDs) as well as their treatments can affect pregnancy and its prognosis. The use of assisted reproductive technologies (ART) can increase the probability of fertility in RDs. The aim of this study was to compare ART outcomes in women with versus without RDs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This retrospective cohort study was carried out between August 2023 and August 2024. Using medical records and documents, the ART outcomes of women with and without RDs were included. The descriptive statistics were provided as mean ± SD, number, and percentage. The distribution status of demographic and clinical variables was done through Mann–Whitney and Chi-squared or Fisher's exact test (for qualitative variables) and the confounder variables were adjusted. Data analysis was performed at a significance level of 5% using SPSS 25 software.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 194 women with 334 cycles of ART were included; 62 participants were with RDs while 132 were without RDs. This study demonstrated that women with RDs are at a significantly higher risk of miscarriage (OR = 5.27, CI 1.28 to 21.75, <i>p</i> = 0.021) and inadequate gestational weight gain during pregnancy (OR = 2.25, CI 1.06 to 4.75, <i>p</i> = 0.034) compared to those without RDs. Additionally, fetal/neonatal complications did not show significant differences between the two groups. However, studies with larger sample sizes may yield different results regarding fetal/neonatal outcomes.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>These results emphasize the importance of personalized and multidisciplinary care for women with RDs, particularly during pregnancy, to manage risks and improve maternal and fetoneonatal outcomes.</p>\n </section>\n </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 7","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assisted Reproductive Technologies Outcomes in Women With Rheumatic Diseases: A Retrospective Cohort Study\",\"authors\":\"Elham Manouchehri, Fatemeh Jalalmarvi, Vahid Ghavami, Zahra Mirfeizi, Nayereh Khadem, Maryam Sahebari\",\"doi\":\"10.1111/1756-185x.70374\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>The multisystem nature of rheumatic diseases (RDs) as well as their treatments can affect pregnancy and its prognosis. 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引用次数: 0
摘要
目的风湿性疾病的多系统性及其治疗方法影响妊娠及其预后。辅助生殖技术（ART）的使用可以增加rd的生育概率。本研究的目的是比较有和没有rd的妇女的ART治疗结果。方法回顾性队列研究于2023年8月至2024年8月进行。利用医疗记录和文件，纳入了有和没有rd的妇女的抗逆转录病毒治疗结果。描述性统计以mean±SD、数字和百分比提供。人口统计学和临床变量的分布情况通过Mann-Whitney和Chi-squared或Fisher精确检验（对于定性变量），并对混杂变量进行调整。数据分析采用SPSS 25软件，显著性水平为5%。结果共纳入194例妇女，接受ART治疗334个周期；62名参与者患有rd， 132名参与者没有rd。该研究表明，与没有rd的女性相比，患有rd的女性流产（OR = 5.27, CI 1.28 ~ 21.75, p = 0.021）和孕期体重增加不足（OR = 2.25, CI 1.06 ~ 4.75, p = 0.034）的风险明显更高。此外，胎儿/新生儿并发症在两组之间没有显着差异。然而，样本量较大的研究可能会产生关于胎儿/新生儿结局的不同结果。这些结果强调了对rd患者进行个性化和多学科护理的重要性，特别是在怀孕期间，以管理风险并改善母胎结局。
Assisted Reproductive Technologies Outcomes in Women With Rheumatic Diseases: A Retrospective Cohort Study
Aim
The multisystem nature of rheumatic diseases (RDs) as well as their treatments can affect pregnancy and its prognosis. The use of assisted reproductive technologies (ART) can increase the probability of fertility in RDs. The aim of this study was to compare ART outcomes in women with versus without RDs.
Methods
This retrospective cohort study was carried out between August 2023 and August 2024. Using medical records and documents, the ART outcomes of women with and without RDs were included. The descriptive statistics were provided as mean ± SD, number, and percentage. The distribution status of demographic and clinical variables was done through Mann–Whitney and Chi-squared or Fisher's exact test (for qualitative variables) and the confounder variables were adjusted. Data analysis was performed at a significance level of 5% using SPSS 25 software.
Results
A total of 194 women with 334 cycles of ART were included; 62 participants were with RDs while 132 were without RDs. This study demonstrated that women with RDs are at a significantly higher risk of miscarriage (OR = 5.27, CI 1.28 to 21.75, p = 0.021) and inadequate gestational weight gain during pregnancy (OR = 2.25, CI 1.06 to 4.75, p = 0.034) compared to those without RDs. Additionally, fetal/neonatal complications did not show significant differences between the two groups. However, studies with larger sample sizes may yield different results regarding fetal/neonatal outcomes.
Conclusions
These results emphasize the importance of personalized and multidisciplinary care for women with RDs, particularly during pregnancy, to manage risks and improve maternal and fetoneonatal outcomes.
期刊介绍：
The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.
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