Sherif M. H. Sanad (Conceptualization Investigation Methodology Project administration Resources Supervision Validation Writing – original draft Writing – review & editing) , Ibrahim S. Sanad (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing)
{"title":"吲哚-1,3-二酮:微波辅助合成环状和螺旋分子体系的多功能前体","authors":"Sherif M. H. Sanad (Conceptualization Investigation Methodology Project administration Resources Supervision Validation Writing – original draft Writing – review & editing) , Ibrahim S. Sanad (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing)","doi":"10.1080/00397911.2025.2492703","DOIUrl":null,"url":null,"abstract":"<div><div>Microwaves are a type of electromagnetic radiation that, when used in chemical reactions, offer a number of advantages, including energy efficiency, reduced reaction time, higher synthesis rate, reduced by-products, well-defined final products, high purity, and improved physicochemical properties. Therefore, microwaves have been widely used in both organic and inorganic synthesis. Cyclic 1,3-diketones are versatile precursors that could be used to prepare diverse molecular systems. Among them, indane-1,3-dione has been widely used to prepare diverse indeno-fused heterocycles and spiro-heterocyclic derivatives that demonstrated numerous biological applications. This review includes a survey of the available reports where indane-1,3-dione is annulated, resulting in heterocycles with bi-, tri-, tetra-, and pentacyclic rings under microwave irradiation. Moreover, the review investigates the utility of microwave-assisted reactions in the synthesis of indanone-based, spiro-molecular systems. The mechanistic postulates of some complex procedures are highlighted. Some comments are added to highlight the biological applications of the indeno-fused products.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"55 14","pages":"Pages 1045-1071"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Indane-1,3-dione: Versatile precursor for the microwave-assisted synthesis of annulated and spiro-molecular systems\",\"authors\":\"Sherif M. H. Sanad (Conceptualization Investigation Methodology Project administration Resources Supervision Validation Writing – original draft Writing – review & editing) , Ibrahim S. Sanad (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing)\",\"doi\":\"10.1080/00397911.2025.2492703\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Microwaves are a type of electromagnetic radiation that, when used in chemical reactions, offer a number of advantages, including energy efficiency, reduced reaction time, higher synthesis rate, reduced by-products, well-defined final products, high purity, and improved physicochemical properties. Therefore, microwaves have been widely used in both organic and inorganic synthesis. Cyclic 1,3-diketones are versatile precursors that could be used to prepare diverse molecular systems. Among them, indane-1,3-dione has been widely used to prepare diverse indeno-fused heterocycles and spiro-heterocyclic derivatives that demonstrated numerous biological applications. This review includes a survey of the available reports where indane-1,3-dione is annulated, resulting in heterocycles with bi-, tri-, tetra-, and pentacyclic rings under microwave irradiation. Moreover, the review investigates the utility of microwave-assisted reactions in the synthesis of indanone-based, spiro-molecular systems. The mechanistic postulates of some complex procedures are highlighted. Some comments are added to highlight the biological applications of the indeno-fused products.</div></div>\",\"PeriodicalId\":22119,\"journal\":{\"name\":\"Synthetic Communications\",\"volume\":\"55 14\",\"pages\":\"Pages 1045-1071\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthetic Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S0039791125000347\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791125000347","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Indane-1,3-dione: Versatile precursor for the microwave-assisted synthesis of annulated and spiro-molecular systems
Microwaves are a type of electromagnetic radiation that, when used in chemical reactions, offer a number of advantages, including energy efficiency, reduced reaction time, higher synthesis rate, reduced by-products, well-defined final products, high purity, and improved physicochemical properties. Therefore, microwaves have been widely used in both organic and inorganic synthesis. Cyclic 1,3-diketones are versatile precursors that could be used to prepare diverse molecular systems. Among them, indane-1,3-dione has been widely used to prepare diverse indeno-fused heterocycles and spiro-heterocyclic derivatives that demonstrated numerous biological applications. This review includes a survey of the available reports where indane-1,3-dione is annulated, resulting in heterocycles with bi-, tri-, tetra-, and pentacyclic rings under microwave irradiation. Moreover, the review investigates the utility of microwave-assisted reactions in the synthesis of indanone-based, spiro-molecular systems. The mechanistic postulates of some complex procedures are highlighted. Some comments are added to highlight the biological applications of the indeno-fused products.
期刊介绍:
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.