中药治疗冠心病调节肠道菌群的研究进展

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2025-07-01 DOI:10.1016/j.chmed.2025.04.007

Qiwen Lu , Sang Luo , Chengyan Guan , Hao Zhang , Haoyue Jia , Qiang Wan

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引用次数: 0

摘要

冠状动脉粥样硬化性心脏病是由动脉粥样硬化引起的主要心血管疾病，以慢性炎症和脂质代谢失调为特征。肠道微生物群在人类健康和疾病中起着至关重要的作用，研究表明肠道微生物代谢与冠心病的发生和进展之间存在密切关联。本文综述了肠道菌群与冠心病的关系，以及中药调节消化道菌群治疗冠心病的机制，系统地阐述了肠道菌群如何通过代谢产物和免疫调节参与冠心病的发生和发展。总结了近年来中药调节肠道菌群治疗冠心病的研究进展。旨在为探索肠道菌群与冠心病的关系，以及中医治疗冠心病的方法提供进一步的参考和见解。

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Research progress of regulating intestinal flora by traditional Chinese medicine in treating coronary heart disease

Coronary atherosclerotic heart disease is a major cardiovascular condition driven by atherosclerosis, distinguished by chronic inflammation and dysregulated lipid metabolism. The gut microbiota plays an essential role in human health and disease, with research indicating a strong association between gut microbial metabolism and the development and progression of coronary heart disease. This article provides a review of the relationship between gut microbiota and coronary heart disease, as well as the mechanisms by which traditional Chinese medicine regulates digestive tract microbiota to treat coronary heart disease, which systematically explains how the gut microbiota, through metabolic products and immune regulation, contributes to the occurrence and progression of coronary heart disease, and summarizes recent advances in research on traditional Chinese medicine’s regulation of gut microbiota for treating coronary heart disease. It aims to provide further reference and insights for exploring the relationship between gut microbiota and coronary heart disease, as well as traditional Chinese medicine approaches for treating coronary heart disease.

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks

期刊介绍： Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.