来源不明的癌症：诊断、治疗和技术进步

IF 2.1 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina Clinica Pub Date : 2025-07-18 DOI:10.1016/j.medcli.2025.107118

Ferran Losa Gaspà , Raquel Legido Díaz , Sheila Sánchez Pérez

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引用次数: 0

摘要

未知原发癌（CUP）是一种临床类型的转移性恶性肿瘤，尽管进行了彻底的诊断评估，原发肿瘤仍未确定。由于其复杂的管理和诊断困难，它在现代肿瘤学中提出了重大挑战。尽管CUP约占全球癌症病例的2%至5%，但最近诊断技术的进步，如免疫组织化学和基因组测序，提高了对CUP进行分类和使用靶向治疗的能力。然而，局限性仍然存在，包括CUP的生物学异质性和经常需要经验性治疗。这篇综述讨论了CUP诊断和治疗的进展，强调了将精确肿瘤学和姑息治疗相结合的多学科方法对提高患者生活质量的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cáncer de origen desconocido: diagnóstico, tratamiento y avances tecnológicos

Cancer of unknown primary (CUP) is a clinical type of metastatic malignancy where the primary tumor remains unidentified despite thorough diagnostic evaluation. It presents a significant challenge in modern oncology due to its complex management and diagnostic difficulties. Although CUP accounts for approximately 2 to 5% of cancer cases worldwide, recent advancements in diagnostic techniques, such as immunohistochemistry and genomic sequencing, have improved the ability to classify and treat CUP using targeted therapies. However, limitations persist, including the biological heterogeneity of CUP and the frequent need for empirical treatments. This review discusses advancements in CUP diagnosis and treatment, emphasizing the importance of a multidisciplinary approach that integrates precision oncology and palliative care to enhance patient quality of life.

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来源期刊

Medicina Clinica 医学-医学：内科

CiteScore

3.10

自引率

5.10%

发文量

295

审稿时长

22 days

期刊介绍： Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.