{"title":"热应激诱导的牛生殖失调:黄体和黄体酮观点的焦点","authors":"Iqra Batool , Rehana Kausar , Tarique Hussain","doi":"10.1016/j.jtherbio.2025.104201","DOIUrl":null,"url":null,"abstract":"<div><div>Global warming and climate change pose significant challenges to cattle reproduction, with heat stress (HS) emerging as a critical factor contributing to infertility and subfertility in dairy cows. Elevated temperatures in high-producing cattle lead to declines in conception rates and increased incidences of early embryonic loss, thereby undermining the economic sustainability of dairy enterprises. HS induces a cascade of physiological, behavioral, and endocrinological responses, which adversely affect reproductive function, particularly through disruptions in corpus luteum (CL) activity and progesterone (P4) production—both essential for estrous cycle regulation and pregnancy maintenance. Prolonged HS exposure results in suppressed P4 secretion, which compromises the uterine environment necessary for embryo survival. This review examines the mechanisms by which HS impacts CL function and P4 synthesis, contributing to reproductive inefficiencies, and discusses evidence-based mitigation strategies, including environmental modifications, nutritional adjustments, hormonal interventions and genetic selection for thermotolerance. Through these insights, this review aims to highlight effective approaches to enhance fertility, reduce subfertility, and improve reproductive resilience in cattle facing HS-induced stress.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"131 ","pages":"Article 104201"},"PeriodicalIF":2.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Heat stress-induced dysregulation of bovine reproduction: A focus on corpus luteum and progesterone perspectives\",\"authors\":\"Iqra Batool , Rehana Kausar , Tarique Hussain\",\"doi\":\"10.1016/j.jtherbio.2025.104201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Global warming and climate change pose significant challenges to cattle reproduction, with heat stress (HS) emerging as a critical factor contributing to infertility and subfertility in dairy cows. Elevated temperatures in high-producing cattle lead to declines in conception rates and increased incidences of early embryonic loss, thereby undermining the economic sustainability of dairy enterprises. HS induces a cascade of physiological, behavioral, and endocrinological responses, which adversely affect reproductive function, particularly through disruptions in corpus luteum (CL) activity and progesterone (P4) production—both essential for estrous cycle regulation and pregnancy maintenance. Prolonged HS exposure results in suppressed P4 secretion, which compromises the uterine environment necessary for embryo survival. This review examines the mechanisms by which HS impacts CL function and P4 synthesis, contributing to reproductive inefficiencies, and discusses evidence-based mitigation strategies, including environmental modifications, nutritional adjustments, hormonal interventions and genetic selection for thermotolerance. Through these insights, this review aims to highlight effective approaches to enhance fertility, reduce subfertility, and improve reproductive resilience in cattle facing HS-induced stress.</div></div>\",\"PeriodicalId\":17428,\"journal\":{\"name\":\"Journal of thermal biology\",\"volume\":\"131 \",\"pages\":\"Article 104201\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of thermal biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306456525001585\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of thermal biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306456525001585","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Heat stress-induced dysregulation of bovine reproduction: A focus on corpus luteum and progesterone perspectives
Global warming and climate change pose significant challenges to cattle reproduction, with heat stress (HS) emerging as a critical factor contributing to infertility and subfertility in dairy cows. Elevated temperatures in high-producing cattle lead to declines in conception rates and increased incidences of early embryonic loss, thereby undermining the economic sustainability of dairy enterprises. HS induces a cascade of physiological, behavioral, and endocrinological responses, which adversely affect reproductive function, particularly through disruptions in corpus luteum (CL) activity and progesterone (P4) production—both essential for estrous cycle regulation and pregnancy maintenance. Prolonged HS exposure results in suppressed P4 secretion, which compromises the uterine environment necessary for embryo survival. This review examines the mechanisms by which HS impacts CL function and P4 synthesis, contributing to reproductive inefficiencies, and discusses evidence-based mitigation strategies, including environmental modifications, nutritional adjustments, hormonal interventions and genetic selection for thermotolerance. Through these insights, this review aims to highlight effective approaches to enhance fertility, reduce subfertility, and improve reproductive resilience in cattle facing HS-induced stress.
期刊介绍:
The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are:
• The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature
• The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature
• Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause
• Effects of temperature on reproduction and development, growth, ageing and life-span
• Studies on modelling heat transfer between organisms and their environment
• The contributions of temperature to effects of climate change on animal species and man
• Studies of conservation biology and physiology related to temperature
• Behavioural and physiological regulation of body temperature including its pathophysiology and fever
• Medical applications of hypo- and hyperthermia
Article types:
• Original articles
• Review articles