免疫功能正常青少年弯曲杆菌性脾脓肿的分子诊断:1例报告及文献复习

IF 1 Q4 INFECTIOUS DISEASES
IDCases Pub Date : 2025-01-01 DOI:10.1016/j.idcr.2025.e02316
Sabeen Zara , Junais Koleri , Maisa Ali , Fatma Abid , Jabeed Parengal , Manal Mahmoud Hamed , Muna Al Maslamani
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引用次数: 0

摘要

脾脓肿是一种罕见的、危及生命的疾病,通常由血液扩散或连续感染引起。我们报告一个14岁的免疫功能正常的男性表现为发烧,腹泻和左上腹疼痛。CT扫描显示14厘米脾脓肿。最初的血液和吸入培养为阴性,经验性头孢曲松和甲硝唑治疗效果不佳。多重PCR胃肠道面板和16S rRNA测序鉴定出空肠弯曲杆菌,促使阿奇霉素和美罗培南靶向治疗。经皮引流和抗生素治疗使病情得以缓解。本病例强调了分子诊断在培养阴性感染中的作用,并强调弯曲杆菌是免疫功能正常患者脾脓肿的罕见病因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular diagnosis of campylobacter splenic abscess in an immunocompetent adolescent: A case report and literature review
Splenic abscess is a rare, life-threatening condition often resulting from hematogenous spread or contiguous infection. We report a 14-year-old immunocompetent male presenting with fever, diarrhea, and left upper quadrant pain. A CT scan revealed a 14-cm splenic abscess. Initial blood and aspirate cultures were negative, and empirical ceftriaxone and metronidazole yielded poor response. Multiplex PCR Gastrointestinal Panel and 16S rRNA sequencing identified Campylobacter jejuni, prompting targeted therapy with azithromycin and meropenem. Percutaneous drainage and antibiotics led to resolution. This case underscores the role of molecular diagnostics in culture-negative infections and highlights Campylobacter as a rare cause of splenic abscess in immunocompetent patients.
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来源期刊
IDCases
IDCases INFECTIOUS DISEASES-
CiteScore
2.60
自引率
6.70%
发文量
300
审稿时长
10 weeks
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