Sabeen Zara , Junais Koleri , Maisa Ali , Fatma Abid , Jabeed Parengal , Manal Mahmoud Hamed , Muna Al Maslamani
{"title":"免疫功能正常青少年弯曲杆菌性脾脓肿的分子诊断:1例报告及文献复习","authors":"Sabeen Zara , Junais Koleri , Maisa Ali , Fatma Abid , Jabeed Parengal , Manal Mahmoud Hamed , Muna Al Maslamani","doi":"10.1016/j.idcr.2025.e02316","DOIUrl":null,"url":null,"abstract":"<div><div>Splenic abscess is a rare, life-threatening condition often resulting from hematogenous spread or contiguous infection. We report a 14-year-old immunocompetent male presenting with fever, diarrhea, and left upper quadrant pain. A CT scan revealed a 14-cm splenic abscess. Initial blood and aspirate cultures were negative, and empirical ceftriaxone and metronidazole yielded poor response. Multiplex PCR Gastrointestinal Panel and 16S rRNA sequencing identified <em>Campylobacter jejuni,</em> prompting targeted therapy with azithromycin and meropenem. Percutaneous drainage and antibiotics led to resolution. This case underscores the role of molecular diagnostics in culture-negative infections and highlights <em>Campylobacter</em> as a rare cause of splenic abscess in immunocompetent patients.</div></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"41 ","pages":"Article e02316"},"PeriodicalIF":1.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular diagnosis of campylobacter splenic abscess in an immunocompetent adolescent: A case report and literature review\",\"authors\":\"Sabeen Zara , Junais Koleri , Maisa Ali , Fatma Abid , Jabeed Parengal , Manal Mahmoud Hamed , Muna Al Maslamani\",\"doi\":\"10.1016/j.idcr.2025.e02316\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Splenic abscess is a rare, life-threatening condition often resulting from hematogenous spread or contiguous infection. We report a 14-year-old immunocompetent male presenting with fever, diarrhea, and left upper quadrant pain. A CT scan revealed a 14-cm splenic abscess. Initial blood and aspirate cultures were negative, and empirical ceftriaxone and metronidazole yielded poor response. Multiplex PCR Gastrointestinal Panel and 16S rRNA sequencing identified <em>Campylobacter jejuni,</em> prompting targeted therapy with azithromycin and meropenem. Percutaneous drainage and antibiotics led to resolution. This case underscores the role of molecular diagnostics in culture-negative infections and highlights <em>Campylobacter</em> as a rare cause of splenic abscess in immunocompetent patients.</div></div>\",\"PeriodicalId\":47045,\"journal\":{\"name\":\"IDCases\",\"volume\":\"41 \",\"pages\":\"Article e02316\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IDCases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214250925001726\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IDCases","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214250925001726","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Molecular diagnosis of campylobacter splenic abscess in an immunocompetent adolescent: A case report and literature review
Splenic abscess is a rare, life-threatening condition often resulting from hematogenous spread or contiguous infection. We report a 14-year-old immunocompetent male presenting with fever, diarrhea, and left upper quadrant pain. A CT scan revealed a 14-cm splenic abscess. Initial blood and aspirate cultures were negative, and empirical ceftriaxone and metronidazole yielded poor response. Multiplex PCR Gastrointestinal Panel and 16S rRNA sequencing identified Campylobacter jejuni, prompting targeted therapy with azithromycin and meropenem. Percutaneous drainage and antibiotics led to resolution. This case underscores the role of molecular diagnostics in culture-negative infections and highlights Campylobacter as a rare cause of splenic abscess in immunocompetent patients.