Amino acid coating enables micromotor operation in physiological conditions.

Physiological environment with high ionic strength will quench the propulsion of micro/nanomotors (MNMs) by suppressing electric double layers, especially for those motors based on electrolyte diffusiophoresis and electrophoresis. Herein, we demonstrate an efficient, general, and simple strategy to improve the ion tolerance of light-driven titanium dioxide (TiO2) micromotors with amino acid surface modification. Compared to the bare TiO2 counterpart, L-arginine (Arg)-treated TiO2 micromotors display over 200 times higher ion tolerance, which is mainly attributed to the increased surface conductivity. This simple ion tolerance improvement strategy can also be applicable to other motors driven by self-electrophoresis. As TiO2 is an efficient sonosensitizer, we combined the light-guiding ability with ultrasound to generate reactive oxygen species to effectively induce in situ tumor apoptosis. We envision that this simple amino acid surface modification can not only provide a solution for MNMs to tolerate the ionic environment but also open up opportunities for further biomedical and translational research of MNMs.