单侧和双侧丘脑底核深部脑刺激的功能网络差异

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-07-17 DOI:10.1038/s41531-025-01064-2

Brendan Santyr, Alexandre Boutet, Mohamad Abbass, Artur Vetkas, Jürgen Germann, Afis Ajala, Jianwei Qiu, Gavin J. B. Elias, Can Sarica, Andrew Z. Yang, Ibrahim Alhashyan, Suneil K. Kalia, Alfonso Fasano, Andres M. Lozano

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引用次数: 0

摘要

单侧或双侧植入是帕金森病深部脑刺激手术的关键考虑因素；然而，不同的治疗效果仍然不完全清楚。在主动刺激期间使用功能性磁共振成像，我们发现双侧刺激加强了关键运动中枢的招募，同时减少了单侧刺激所见的非运动反应，并与改善的结果相关。这提示了双侧刺激后运动功能改善的潜在机制基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus

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Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus

Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson’s disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bilateral stimulation reinforces the recruitment of key motor hubs while reducing non-motor responses seen with unilateral stimulation and correlates with improved outcomes. This suggests a potential mechanistic basis for better motor function following bilateral stimulation.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.