FAP-α在软组织和骨肉瘤：一个新的潜在的诊断和治疗的生物标志物在精准医学时代。

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2025-07-14 DOI:10.1016/j.critrevonc.2025.104852

Alessandra Bracigliano , Ottavia Clemente , Annarita Peddio , Giuseppina Della Vittoria Scarpati , Antonio Pizzolorusso , Lucia Cannella , Fernanda Picozzi , Carmela Garosi , Federica Papa , Flavia Balzamo , Salvatore Tafuto

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引用次数: 0

摘要

成纤维细胞活化蛋白α (FAP-α)是一种在肿瘤微环境中由间充质细胞表达的膜结合丝氨酸蛋白酶。由于其参与多种肿瘤的发生，特别是肉瘤的间质起源，它引起了极大的关注。本文就FAP-α的生物学功能及其在肉瘤病理生理中的意义作一综述。了解FAP-α作为肉瘤诊断和治疗靶点的潜在适用性可以为靶向治疗提供新的途径，并改善患者的预后。

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FAP-α in soft tissue and bone sarcomas: A new potential diagnostic and therapeutic biomarker in the era of precision medicine

Fibroblast activation protein alpha (FAP-α) is a membrane-bound serine protease expressed by mesenchymal cells within the tumor microenvironment. It has garnered significant attention due to its involvement in tumorigenesis in several neoplasms, with a specific attention in sarcomas due to their mesenchymal origin. In this review, the authors explore the biological functions of FAP-α and its implications in sarcoma pathophysiology. Understanding the potential applicability of FAP-α as a diagnostic and therapeutic target in sarcoma could provide new avenues for targeted therapies and improve patient outcomes.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.