Kang-Kang Zhong, Rui Yang, Xue-Chun Liu, Jie He, Chuan-Ting Wen, Zhi-Wei Zhu, Ming-Xuan Fan, Teng Bao, Qi Zhong
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引用次数: 0
摘要
以前的研究主要集中在臭氧暴露和早产(PTB)的影响上,但研究结果存在争议,怀孕期间臭氧暴露的易感窗口期仍然没有定论。在此,我们汇集了现有的证据来探讨母亲O3暴露与PTB之间的关系,并进一步确定了易感暴露窗口。我们通过Embase、PubMed和Web of Science检索到2024年9月9日,对17项符合条件的研究进行了荟萃分析。提取比值比(OR)和相应的95%置信区间(CIs)进行分析。使用Stata 15.0 (StataCorp, College Station, TX, USA)对研究间的异质性、敏感性和发表偏倚进行检验。综合结果显示O3暴露与PTB呈正相关(n=13;OR 1.065 [95% CI 1.056 ~ 1.073]),妊娠中期(13 ~ 27孕周)可能是O3暴露与PTB的易感窗口期(n=11;OR 1.033 [95% CI 1.029 ~ 1.036])。这项荟萃分析表明,怀孕期间暴露于臭氧可能单独增加PTB的风险,13-27孕周是预防这种风险的关键窗口期。在怀孕期间减少户外活动或佩戴防护口罩和补充多种微量营养素可能会降低肺结核患者接触臭氧的风险。
Susceptible window identification of the relationship between maternal ozone exposure and preterm birth.
Previous studies have focused on the effects of ozone (O3) exposure and preterm birth (PTB), but the findings are contentious and the susceptible window for O3 exposure during pregnancy remains inconclusive. Here, we pooled the current evidence to explore the relationship between maternal O3 exposure and PTB and further identified the susceptible exposure windows. We pooled a meta-analysis of 17 eligible studies by searching Embase, PubMed and Web of Science through 9 September 2024. The odds ratio (OR) and the corresponding 95% confidence intervals (CIs) were extracted for analysis. The tests for heterogeneity, sensitivity and publication bias between studies were performed using Stata 15.0 (StataCorp, College Station, TX, USA). The combined results showed a positive association between O3 exposure and PTB (n=13; OR 1.065 [95% CI 1.056 to 1.073]), and middle pregnancy (gestational weeks 13-27) may be a susceptible window of O3 exposure with PTB (n=11; OR 1.033 [95% CI 1.029 to 1.036]). This meta-analysis suggested that O3 exposure during pregnancy may independently increase the risk of PTB and gestational weeks the 13-27 is a critical window for preventing this risk. Reducing outdoor activity or a wearing protective mask and multiple micronutrients supplementation during pregnancy may reduce the risk of O3 exposure in PTB.
期刊介绍:
International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions.
It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.