埃塞俄比亚新生儿坏死性小肠结肠炎的患病率和预测因素:一项系统回顾和荟萃分析。

IF 2.2 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Bikila Balis, Magarsa Lami, Ibsa Musa, Usmael Jibro, Abdi Birhanu, Tesfaye Assebe Yadeta
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引用次数: 0

摘要

撒哈拉以南非洲国家的新生儿死亡占全球新生儿死亡负担的80%。据估计,2019年埃塞俄比亚每1000名活产婴儿中有30人死亡。新生儿坏死性小肠结肠炎(NEC)是导致这些死亡的最常见因素。然而,在埃塞俄比亚没有新生儿NEC的有力证据。因此,本研究旨在确定埃塞俄比亚新生儿重症监护病房新生儿NEC的总患病率及其预测因素。数据库(Scopus, CINAHL, CAB Abstract, Embase, PubMed, Web of Science,谷歌和谷歌Scholar)和参考文献列表用于检索埃塞俄比亚的文献。采用Stata version 17 (StataCorp, College Station, TX, USA)进行分析,采用随机效应模型确定结果变量的比值比(ORs)。通过I2和p值的计算值来评估研究之间的异质性。此外,还采用敏感性分析和漏斗图来评估汇总值对异常值和发表偏倚的稳定性。本研究共纳入12项研究,样本量为7675人。新生儿NEC的总患病率为16%(95%可信区间为11 ~ 22)。meta分析和敏感性分析显示合并or的稳定性,漏斗图没有显示发表偏倚。早产、极低出生体重和在新生儿重症监护病房(NICU)的停留时间被确定为新生儿NEC的预测因素。在埃塞俄比亚,六分之一(16%)入住新生儿重症监护病房的新生儿患有NEC,早产、极低的出生体重和在新生儿重症监护病房的停留时间被确定为关键预测因素。此外,这些发现意味着需要有针对性的干预措施,通过为母亲和儿童提供高质量的医疗保健,采用大规模预防策略,降低易感新生儿出现这种情况的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of neonatal necrotizing enterocolitis and predictors in Ethiopia: a systematic review and meta-analysis.

Neonatal death in sub-Saharan African countries accounts for 80% of the global burden. An estimated 30 deaths per 1000 live births occurred in Ethiopia in 2019. Neonatal necrotizing enterocolitis (NEC) is the most common contributing factor to these deaths. Nevertheless, there is no strong evidence of neonatal NEC in Ethiopia. Therefore, this study aimed to determine the pooled prevalence of neonatal NEC and its predictors among neonates admitted to neonatal intensive care units in Ethiopia. Databases (Scopus, CINAHL, CAB Abstract, Embase, PubMed, Web of Science, Google and Google Scholar) and lists of references were used to search literature in Ethiopia. Stata version 17 (StataCorp, College Station, TX, USA) was used for analysis and the odds ratios (ORs) of the outcome variable were determined using the random-effects model. Heterogeneity among the studies was assessed by computing values for I2 and p-values. Also, sensitivity analysis and funnel plots were used to assess the stability of pooled values to outliers and publication bias. A total of 12 studies with a sample size of 7675 were included in this study. The overall prevalence of neonatal NEC was 16% (95% confidence interval 11 to 22). Meta-analyses and sensitivity analyses showed the stability of the pooled ORs and the funnel plots did not show publication bias. Preterm birth, very low birth weight and duration of stay in a neonatal intensive care unit (NICU) were identified as predictors of neonatal NEC. In Ethiopia, one in six (16%) neonates admitted to NICUs had NEC, with preterm birth, very low birth weight and duration of stay in the NICU identified as key predictors. Moreover, these findings imply the need for targeted interventions to reduce the risk of this condition in vulnerable neonates using large-scale prevention strategies through high-quality healthcare for mothers and children.

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来源期刊
International Health
International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
4.50
自引率
0.00%
发文量
83
审稿时长
>12 weeks
期刊介绍: International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.
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