蛋白酰化在病毒感染调控中的作用及机制。

IF 5.4 1区农林科学 Q1 IMMUNOLOGY

Virulence Pub Date : 2025-12-01 Epub Date: 2025-07-17 DOI:10.1080/21505594.2025.2530171

Lei Song, Ziang Wei, Pan Shang, Shijie Hu, Lei Chen, Lili Niu, Yan Wang, Mailin Gan, Linyuan Shen, Li Zhu, Ye Zhao

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引用次数: 0

摘要

蛋白质酰化修饰是蛋白质翻译后最重要的修饰之一，它通过在蛋白质残基上添加酰基来调节蛋白质的功能。蛋白酰化在病毒感染中起着至关重要的作用。酰化可以影响病毒蛋白，从而调节病毒进入、复制和组装等过程。此外，酰化还通过调节干扰素通路、细胞代谢和信号转导来调节病毒感染。本文主要阐述乙酰化、琥珀酰化和棕榈酰化在病毒感染调控中的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The function and mechanism of protein acylation in the regulation of viral infection.

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The function and mechanism of protein acylation in the regulation of viral infection.

Protein acylation modification is one of the most important protein post-translational modifications, which regulates the function of the protein by adding acyl groups to the residues of the protein. Protein acylation plays a crucial role in viral infection. Acylation can influence viral proteins, thereby regulating processes such as viral entry, replication, and assembly. Additionally, acylation regulates viral infection by regulating interferon pathway, cell metabolism, and signal transduction. This paper mainly elucidates the mechanism of acetylation, succinylation, and palmitoylation in the regulation of viral infection.

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来源期刊

Virulence IMMUNOLOGY-MICROBIOLOGY

CiteScore

9.20

自引率

1.90%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.