{"title":"运动皮质和多巴胺能输入对小鼠纹状体节律性运动的调节。","authors":"Hua Zhang, Yunxiao Su, Xujun Wu, Wen-Biao Gan","doi":"10.1186/s13041-025-01232-8","DOIUrl":null,"url":null,"abstract":"<p><p>The striatum is a critical component of the basal ganglia and plays a central role in regulating motor initiation and action selection. How cortical and subcortical inputs converging at the striatum regulate locomotion remains unclear. By examining gait changes in head-fixed mice running on a treadmill, we found that mice were capable of performing forward, but not backward, rhythmic locomotion using their forelimbs when the striatum and motor cortex were inactivated. The striatal activity is critical for adjusting initially disorganized gait to efficient rhythmic locomotion during forward running training, as well as for increasing the stride width during forward locomotion. The inputs from the motor cortex to striatum are important for the rhythmic locomotion, but not for changes of stride length and width during forward running training. In addition, D1 and D2 dopamine receptor activity in striatum are both important for efficient rhythmic locomotion, while exerting opposite effects on the stride width. Together, these results reveal multifactorial control of efficient and rhythmic gait by motor cortical and dopaminergic inputs converging at the striatum.</p>","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"63"},"PeriodicalIF":2.9000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269160/pdf/","citationCount":"0","resultStr":"{\"title\":\"The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum.\",\"authors\":\"Hua Zhang, Yunxiao Su, Xujun Wu, Wen-Biao Gan\",\"doi\":\"10.1186/s13041-025-01232-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The striatum is a critical component of the basal ganglia and plays a central role in regulating motor initiation and action selection. How cortical and subcortical inputs converging at the striatum regulate locomotion remains unclear. By examining gait changes in head-fixed mice running on a treadmill, we found that mice were capable of performing forward, but not backward, rhythmic locomotion using their forelimbs when the striatum and motor cortex were inactivated. The striatal activity is critical for adjusting initially disorganized gait to efficient rhythmic locomotion during forward running training, as well as for increasing the stride width during forward locomotion. The inputs from the motor cortex to striatum are important for the rhythmic locomotion, but not for changes of stride length and width during forward running training. In addition, D1 and D2 dopamine receptor activity in striatum are both important for efficient rhythmic locomotion, while exerting opposite effects on the stride width. Together, these results reveal multifactorial control of efficient and rhythmic gait by motor cortical and dopaminergic inputs converging at the striatum.</p>\",\"PeriodicalId\":18851,\"journal\":{\"name\":\"Molecular Brain\",\"volume\":\"18 1\",\"pages\":\"63\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269160/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Brain\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13041-025-01232-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Brain","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13041-025-01232-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum.
The striatum is a critical component of the basal ganglia and plays a central role in regulating motor initiation and action selection. How cortical and subcortical inputs converging at the striatum regulate locomotion remains unclear. By examining gait changes in head-fixed mice running on a treadmill, we found that mice were capable of performing forward, but not backward, rhythmic locomotion using their forelimbs when the striatum and motor cortex were inactivated. The striatal activity is critical for adjusting initially disorganized gait to efficient rhythmic locomotion during forward running training, as well as for increasing the stride width during forward locomotion. The inputs from the motor cortex to striatum are important for the rhythmic locomotion, but not for changes of stride length and width during forward running training. In addition, D1 and D2 dopamine receptor activity in striatum are both important for efficient rhythmic locomotion, while exerting opposite effects on the stride width. Together, these results reveal multifactorial control of efficient and rhythmic gait by motor cortical and dopaminergic inputs converging at the striatum.
期刊介绍:
Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings.
Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.