运动皮质和多巴胺能输入对小鼠纹状体节律性运动的调节。

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Hua Zhang, Yunxiao Su, Xujun Wu, Wen-Biao Gan
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引用次数: 0

摘要

纹状体是基底神经节的重要组成部分,在调节运动启动和动作选择中起着核心作用。皮层和皮层下输入如何在纹状体聚集调节运动尚不清楚。通过检查头部固定的小鼠在跑步机上跑步的步态变化,我们发现当纹状体和运动皮层失活时,小鼠能够使用前肢进行向前而不是向后的有节奏的运动。纹状体的活动是关键的调整最初无序的步态到有效的有节奏的运动在向前跑训练,以及增加跨步宽度在向前运动。运动皮层向纹状体的输入对节奏运动有重要影响,但对前跑训练中步幅和步幅的变化影响不大。此外,纹状体中D1和D2多巴胺受体的活性对有效的节奏运动都很重要,而对步幅的影响相反。总之,这些结果揭示了运动皮质和多巴胺能输入在纹状体聚集的多因素控制高效和有节奏的步态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum.

The striatum is a critical component of the basal ganglia and plays a central role in regulating motor initiation and action selection. How cortical and subcortical inputs converging at the striatum regulate locomotion remains unclear. By examining gait changes in head-fixed mice running on a treadmill, we found that mice were capable of performing forward, but not backward, rhythmic locomotion using their forelimbs when the striatum and motor cortex were inactivated. The striatal activity is critical for adjusting initially disorganized gait to efficient rhythmic locomotion during forward running training, as well as for increasing the stride width during forward locomotion. The inputs from the motor cortex to striatum are important for the rhythmic locomotion, but not for changes of stride length and width during forward running training. In addition, D1 and D2 dopamine receptor activity in striatum are both important for efficient rhythmic locomotion, while exerting opposite effects on the stride width. Together, these results reveal multifactorial control of efficient and rhythmic gait by motor cortical and dopaminergic inputs converging at the striatum.

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来源期刊
Molecular Brain
Molecular Brain NEUROSCIENCES-
CiteScore
7.30
自引率
0.00%
发文量
97
审稿时长
>12 weeks
期刊介绍: Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.
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