David Longhino, Ilaria Baglivo, Maria Antonietta Zavarella, Stefania Colantuono, Chiara Laface, Gabriele Lucca, Laura Bruno, Fabio Romano Selvi, Vincenzo Patella, Aikaterini Detoraki, Rosa Buonagura, Caterina Tatarelli, Barbara Moscatelli, Serena D'Avelli, Elisabetta Abruzzese, Elisabetta Greco, Antonio Gasbarrini, Livio Pagano, Marianna Criscuolo, Sabrina Giammarco, Cristiano Caruso
{"title":"高嗜酸性粒细胞综合征的临床和免疫生物标志物：诊断算法后的第二步。","authors":"David Longhino, Ilaria Baglivo, Maria Antonietta Zavarella, Stefania Colantuono, Chiara Laface, Gabriele Lucca, Laura Bruno, Fabio Romano Selvi, Vincenzo Patella, Aikaterini Detoraki, Rosa Buonagura, Caterina Tatarelli, Barbara Moscatelli, Serena D'Avelli, Elisabetta Abruzzese, Elisabetta Greco, Antonio Gasbarrini, Livio Pagano, Marianna Criscuolo, Sabrina Giammarco, Cristiano Caruso","doi":"10.3389/fmed.2025.1600728","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Idiopathic hypereosinophilic syndrome currently represents a major unmet need for all medical specialties dealing with this disease. Markers capable of characterising the wide variability of its clinical presentation are currently lacking.</p><p><strong>Objective: </strong>This study aims to evaluate a panel of possible markers in idiopathic hypereosinophilic syndrome.</p><p><strong>Methods: </strong>In this pilot prospective single-centre cohort study, we analysed clinical (age, years of disease, steroid therapy) and laboratory (absolute eosinophil count, total IgE antibodies, IgE antibodies against Staphylococcus aureus enterotoxins, serum eosinophil cationic protein, serum immunoglobulin free light chains k and λ and their ratio) data obtained from 21 patients suffering from idiopathic hypereosinophilic syndrome from June 2023 to December 2024.</p><p><strong>Results: </strong>Mean absolute eosinophilic count was 3758.57 cells/μL. 17 patients were receiving treatment with > 7.5 mg of prednisone or equivalent at the time of the diagnosis. 13 patients had positive Staphylococcus aureus enterotoxins IgE, while the mean total serum IgE was 241.64 kU/L. We observed a high serum eosinophil cationic protein value as well as a high serum κ free light chain, while serum λ and κ/λ were normal. Patients with higher absolute eosinophilic count had higher eosinophil cationic protein levels (<i>p</i> < 0.05), such as higher steroid consumption (<i>p</i> < 0.05). In addition, we found a strong association between high κ free light chain levels and high previous steroid use and with Staphylococcus aureus enterotoxins IgE positivity.</p><p><strong>Conclusion: </strong>Our results could increase the number of possible biomarkers for risk stratification in idiopathic hypereosinophilic syndrome.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1600728"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263904/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms.\",\"authors\":\"David Longhino, Ilaria Baglivo, Maria Antonietta Zavarella, Stefania Colantuono, Chiara Laface, Gabriele Lucca, Laura Bruno, Fabio Romano Selvi, Vincenzo Patella, Aikaterini Detoraki, Rosa Buonagura, Caterina Tatarelli, Barbara Moscatelli, Serena D'Avelli, Elisabetta Abruzzese, Elisabetta Greco, Antonio Gasbarrini, Livio Pagano, Marianna Criscuolo, Sabrina Giammarco, Cristiano Caruso\",\"doi\":\"10.3389/fmed.2025.1600728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Idiopathic hypereosinophilic syndrome currently represents a major unmet need for all medical specialties dealing with this disease. Markers capable of characterising the wide variability of its clinical presentation are currently lacking.</p><p><strong>Objective: </strong>This study aims to evaluate a panel of possible markers in idiopathic hypereosinophilic syndrome.</p><p><strong>Methods: </strong>In this pilot prospective single-centre cohort study, we analysed clinical (age, years of disease, steroid therapy) and laboratory (absolute eosinophil count, total IgE antibodies, IgE antibodies against Staphylococcus aureus enterotoxins, serum eosinophil cationic protein, serum immunoglobulin free light chains k and λ and their ratio) data obtained from 21 patients suffering from idiopathic hypereosinophilic syndrome from June 2023 to December 2024.</p><p><strong>Results: </strong>Mean absolute eosinophilic count was 3758.57 cells/μL. 17 patients were receiving treatment with > 7.5 mg of prednisone or equivalent at the time of the diagnosis. 13 patients had positive Staphylococcus aureus enterotoxins IgE, while the mean total serum IgE was 241.64 kU/L. We observed a high serum eosinophil cationic protein value as well as a high serum κ free light chain, while serum λ and κ/λ were normal. Patients with higher absolute eosinophilic count had higher eosinophil cationic protein levels (<i>p</i> < 0.05), such as higher steroid consumption (<i>p</i> < 0.05). In addition, we found a strong association between high κ free light chain levels and high previous steroid use and with Staphylococcus aureus enterotoxins IgE positivity.</p><p><strong>Conclusion: </strong>Our results could increase the number of possible biomarkers for risk stratification in idiopathic hypereosinophilic syndrome.</p>\",\"PeriodicalId\":12488,\"journal\":{\"name\":\"Frontiers in Medicine\",\"volume\":\"12 \",\"pages\":\"1600728\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263904/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fmed.2025.1600728\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1600728","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Clinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms.
Background: Idiopathic hypereosinophilic syndrome currently represents a major unmet need for all medical specialties dealing with this disease. Markers capable of characterising the wide variability of its clinical presentation are currently lacking.
Objective: This study aims to evaluate a panel of possible markers in idiopathic hypereosinophilic syndrome.
Methods: In this pilot prospective single-centre cohort study, we analysed clinical (age, years of disease, steroid therapy) and laboratory (absolute eosinophil count, total IgE antibodies, IgE antibodies against Staphylococcus aureus enterotoxins, serum eosinophil cationic protein, serum immunoglobulin free light chains k and λ and their ratio) data obtained from 21 patients suffering from idiopathic hypereosinophilic syndrome from June 2023 to December 2024.
Results: Mean absolute eosinophilic count was 3758.57 cells/μL. 17 patients were receiving treatment with > 7.5 mg of prednisone or equivalent at the time of the diagnosis. 13 patients had positive Staphylococcus aureus enterotoxins IgE, while the mean total serum IgE was 241.64 kU/L. We observed a high serum eosinophil cationic protein value as well as a high serum κ free light chain, while serum λ and κ/λ were normal. Patients with higher absolute eosinophilic count had higher eosinophil cationic protein levels (p < 0.05), such as higher steroid consumption (p < 0.05). In addition, we found a strong association between high κ free light chain levels and high previous steroid use and with Staphylococcus aureus enterotoxins IgE positivity.
Conclusion: Our results could increase the number of possible biomarkers for risk stratification in idiopathic hypereosinophilic syndrome.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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